Triglyceride-glucose index predicts major adverse cardiovascular events in patients with chronic kidney disease

被引：7

作者：

Li, Kangbo ^{[1
]}

Hou, Qiqi ^{[2
]}

Li, Xinyi ^{[3
]}

Tian, Liying ^{[4
]}

Wang, Liyan ^{[5
]}

Wu, Shouling ^{[6
]}

Han, Quanle ^{[5
]}

机构：

[1] Wenfeng Dist Xiguan Subdist Off Community Hlth Ctr, Dept Internal Med, Anyang, Peoples R China

[2] Hebei Med Univ, Shijiazhuang, Peoples R China

[3] Xiangnan Univ, Sch Clin Med, Chenzhou, Peoples R China

[4] Tangshan Gongren Hosp, Catheterizat Unit, Tangshan, Peoples R China

[5] Tangshan Gongren Hosp, Dept Cardiol, Tangshan, Peoples R China

[6] Kailuan Gen Hosp, Dept Cardiol, Tangshan, Peoples R China

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2024年 / 56卷 / 08期

关键词：

Triglyceride-glucose index; Insulin resistance; Major adverse cardiovascular events; Chronic kidney disease; ELEVATION MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; RISK; THERAPIES; MORTALITY; STROKE; DEATH;

D O I：

10.1007/s11255-024-04005-9

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background and purposeTriglyceride-glucose (TyG) index has been regarded as a reliable surrogate marker of insulin resistance for predicting cardiovascular outcomes. The current study aimed to explore the associations between TyG index with major adverse cardiovascular events (MACE) in patients with chronic kidney disease (CKD).Methods/patients13,517 patients with chronic kidney disease (CKD) from the Kailuan study were included. Patients were divided into quartiles according to the TyG index. The outcomes were MACE, including acute myocardial infarction (AMI) and ischemic stroke (IS). The association between TyG index and the risk of MACE was analyzed by Cox regression models.ResultsDuring 13.87-year follow-up, a total 1356 MACEs occurred. Multivariable Cox proportional-hazards analyses showed that a higher TyG index quartile was associated with an elevated risk of MACE.ConclusionsTyG index is significantly related to MACE in patients with CKD. TyG index can be regarded as a novel predictor of MACE for patients with CKD.

引用

页码：2793 / 2802

页数：10

共 47 条

[1] Diabetic Kidney Disease Challenges, Progress, and Possibilities [J].

Alicic, Radica Z. ;

Rooney, Michele T. ;

Tuttle, Katherine R. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 12 (12) :2032-2045

[2] The impact of triglyceride-glucose index on incident cardiovascular events during 16 years of follow-up: Tehran Lipid and Glucose Study [J].

Barzegar, Niloofar ;

Tohidi, Maryam ;

Hasheminia, Mitra ;

Azizi, Fereidoun ;

Hadaegh, Farzad .

CARDIOVASCULAR DIABETOLOGY, 2020, 19 (01)

[3] Stroke risk and outcomes in patients with chronic kidney disease or end-stage renal disease: Two nationwide studies [J].

Cherng, Yih-Giun ;

Lin, Chao-Shun ;

Shih, Chun-Chuan ;

Hsu, Yung-Ho ;

Yeh, Chun-Chieh ;

Hu, Chaur-Jong ;

Chen, Ta-Liang ;

Liao, Chien-Chang .

PLOS ONE, 2018, 13 (01)

[4]

Chung MC., 2018, Neuropsychiatry (London), V8, P587

[5] The global burden of chronic kidney disease [J].

Cockwell, Paul ;

Fisher, Lori-Ann .

LANCET, 2020, 395 (10225) :662-664

[6] The Evolution and Refinement of Traditional Risk Factors for Cardiovascular Disease [J].

deGoma, Emil M. ;

Knowles, Joshua W. ;

Angeli, Fabio ;

Budoff, Matthew J. ;

Rader, Daniel J. .

CARDIOLOGY IN REVIEW, 2012, 20 (03) :118-129

[7] Chronic kidney disease and risk of major cardiovascular disease and non-vascular mortality: prospective population based cohort study [J].

Di Angelantonio, Emanuele ;

Chowdhury, Rajiv ;

Sarwar, Nadeem ;

Aspelund, Thor ;

Danesh, John ;

Gudnason, Vilmundur .

BMJ-BRITISH MEDICAL JOURNAL, 2010, 341 :768

[8] Risk factors associated with major adverse cardiac and cerebrovascular events following percutaneous coronary intervention: a 10-year follow-up comparing random survival forest and Cox proportional-hazards model [J].

Farhadian, Maryam ;

Dehdar Karsidani, Sahar ;

Mozayanimonfared, Azadeh ;

Mahjub, Hossein .

BMC CARDIOVASCULAR DISORDERS, 2021, 21 (01)

[9] Use of Evidence-Based Therapies in Short-Term Outcomes of ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Myocardial Infarction in Patients With Chronic Kidney Disease A Report From the National Cardiovascular Data Acute Coronary Treatment and Intervention Outcomes Network Registry [J].

Fox, Caroline S. ;

Muntner, Paul ;

Chen, Anita Y. ;

Alexander, Karen P. ;

Roe, Matthew T. ;

Cannon, Christopher P. ;

Saucedo, Jorge F. ;

Kontos, Michael C. ;

Wiviott, Stephen D. .

CIRCULATION, 2010, 121 (03) :357-U33

[10] Insulin resistance and cardiovascular disease [J].

Ginsberg, HN .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (04) :453-458

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