Nanomaterials for Anti-Infection in Orthopedic Implants: A Review

被引：2

作者：

Sui, Junhao ^{[1
]}

Hou, Yijin ^{[2
]}

Chen, Mengchen ^{[1
]}

Zheng, Zhong ^{[1
]}

Meng, Xiangyu ^{[1
]}

Liu, Lu ^{[1
]}

Huo, Shicheng ^{[3
]}

Liu, Shu ^{[4
]}

Zhang, Hao ^{[1
]}

机构：

[1] Navy Med Univ, Changhai Hosp, Dept Orthoped, Shanghai 200433, Peoples R China

[2] Univ Shanghai Sci & Technol, Sch Med Instrument & Food Engn, Shanghai 200093, Peoples R China

[3] Navy Med Univ, Changzheng Hosp, Spine Ctr, Dept Orthoped Surg, Shanghai 200003, Peoples R China

[4] Navy Med Univ, Changhai Hosp, Dept Spine Surg, Shanghai 200433, Peoples R China

来源：

COATINGS | 2024年 / 14卷 / 03期

关键词：

nanomaterials; antimicrobial; orthopedic implants; BIOGENIC SELENIUM NANOPARTICLES; WALLED CARBON NANOTUBES; ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; SILVER NANOPARTICLES; ANTIMICROBIAL ACTIVITY; OXIDE NANOPARTICLES; IN-VITRO; PSEUDOMONAS-AERUGINOSA; MOLECULAR-MECHANISMS;

D O I：

10.3390/coatings14030254

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Postoperative implant infection is a severe complication in orthopedic surgery, often leading to implant failure. Current treatment strategies mainly rely on systemic antibiotic therapies, despite contributing to increasing bacterial resistance. In recent years, nanomaterials have gained attention for their potential in anti-infection methods. They exhibit more substantial bactericidal effects and lower drug resistance than conventional antimicrobial agents. Nanomaterials also possess multiple bactericidal mechanisms, such as physico-mechanical interactions. Additionally, they can serve as carriers for localized antimicrobial delivery. This review explores recent applications of nanomaterials with different morphologies in post-orthopedic surgery infections and categorizes their bactericidal mechanisms.

引用

页数：27

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