Misperceptions and management of LDL-cholesterol in secondary prevention of patients with familial hypercholesterolemia in cardiology practice: Real-life evidence from the EPHESUS registry

被引：5

作者：

Kayikcioglu, Meral ^{[1
,25
]}

Basaran, Oezcan ^{[2
]}

Dogan, Volkan ^{[2
]}

Mert, Kadir Ugur ^{[3
]}

Mert, Gurbet oezge

Ozdemir, Ibrahim Halil ^{[4
]}

Rencazogullari, Ibrahim ^{[5
]}

Karadeniz, Fatma oezpamuk ^{[6
]}

Tekinalp, Mehmet ^{[7
]}

Askin, Lutfu ^{[8
]}

Demirelli, Selami ^{[9
]}

Gencer, Erkan ^{[10
]}

Bekar, Lutfu ^{[11
]}

Aktas, Mujdat ^{[12
]}

Resulzade, Mubariz Murat ^{[13
]}

Kalcik, Macit ^{[11
]}

Aksan, Goekhan ^{[14
,18
]}

Cinier, Goeksel ^{[15
]}

Akay, Kadriye Halli ^{[16
]}

Pekel, Nihat ^{[17
]}

Senol, Utku ^{[19
]}

Demir, Vahit ^{[20
]}

Inci, Sinan ^{[21
]}

Dervis, Emir ^{[22
]}

Oezlek, Bulent ^{[2
]}

Ozlek, Eda ^{[2
]}

Celik, Oguzhan ^{[2
]}

Cil, Cem ^{[23
]}

Biteker, Murat ^{[24
]}

机构：

[1] Ege Univ, Fac Med, Dept Cardiol, Izmir, Turkiye

[2] Mugla Sitki Kocman Univ, Fac Med, Dept Cardiol, Mugla, Turkiye

[3] Eskisehir Osmangazi Univ, Dept Cardiol, Fac Med, Eskisehir, Turkiye

[4] Manisa City Hosp, Dept Cardiol, Manisa, Turkiye

[5] Kafkas Univ, Fac Med, Dept Cardiol, Kars, Turkiye

[6] Karamanoglu Mehmetbey Univ, Dept Cardiol, Fac Med, Karaman, Turkiye

[7] Necip Fazil State Hosp, Dept Cardiol, Kahramanmaras, Turkiye

[8] Dr Ersin Arslan Educ & Res Hosp, Dept Cardiol, Gaziantep, Turkiye

[9] Kayseri City Hosp, Dept Cardiol, Kayseri, Turkiye

[10] Sanliurfa Mehmet Akif Inan Educ & Res Hosp, Dept Cardiol, Sanliurfa, Turkiye

[11] Hitit Univ, Fac Med, Dept Cardiol, Corum, Turkiye

[12] Arnavutkoy State Hosp, Dept Cardiol, Istanbul, Turkiye

[13] Private Eren Hosp, Dept Cardiol, Istanbul, Turkiye

[14] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkiye

[15] Dept Cardiol, Siyami Ersek Educ & Res Hsopital, Istanbul, Turkiye

[16] Kocaeli State Hosp, Dept Cardiol, Kocaeli, Turkiye

[17] Tekden Private Hosp Denizli, Dept Cardiol, Denizli, Turkiye

[18] Siyami Ersek Educ & Res Hsopital, Samsun, Turkiye

[19] EskisehirAcibadem Hosp, Dept Cardiol, Eskisehir, Turkiye

[20] Yozgat City Hosp, Dept Cardiol, Yozgat, Turkiye

[21] Aksaray Univ, Fac Med, Dept Cardiol, Aksaray, Turkiye

[22] Medipol Univ, Fac Med, Dept Cardiol, Istanbul, Turkiye

[23] Medlife Med Ctr, Dept Cardiol, Mugla, Turkiye

[24] Private Lokman Hekim Esnaf Hosp, Dept Cardiol, Fethiye, Mugla, Turkiye

[25] Ege Univ, Fac Med, Dept Cardiol, Izmir, Turkiye

来源：

JOURNAL OF CLINICAL LIPIDOLOGY | 2023年 / 17卷 / 06期

关键词：

Familial hypercholesterolemia; Atherosclerotic cardiovascular disease; Secondary prevention; Lipid-lowering therapy; LDL-cholesterol; Media coverage; EXPERIENCE;

D O I：

10.1016/j.jacl.2023.09.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a common inherited disease, leading to premature atherosclerotic cardiovascular disease (ASCVD) due to elevated low-density lipoprotein cholesterol (LDL-C) levels. Achieving LDL-C goals is extremely important for preventing the complications of this fatal disease. We evaluated the management of FH patients with ASCVD in cardiology practice. METHODS: We analyzed patients with ASCVD from the nationwide EPHESUS registry, which was conducted in 40 cardiology outpatient clinics, and compared those with and without FH. RESULTS: Of the 1482 consecutively enrolled patients with ASCVD, 618 (41.7%) had FH, among which 455 were categorized as 'Possible FH' and 163 as 'Probable or Definite FH'. Proposed LDL-C goals were not attained in more than 90% of the patients with FH. The proportion of those on statin therapy was 77% for possible and 91% for probable or definite FH, whereas 34.2 % and 59.4% were in use of high-intensity statins, respectively. None of the patients were on PCSK-9 inhibitors, and only 2 used ezetimibe. Adverse media coverage was the most common cause of statin discontinuation (32.5% in 'possible FH' and 45.7% in 'probable/definite FH'). The negative impact of media in the decision to stop lipid lowering therapy (LLT) was increasing with education level. CONCLUSIONS: In real life most of the FH patients with ASCVD are undertreated in cardiology practice regarding statin dosing and combined LLT. Drug discontinuation rates are notably high and are mostly media-related, and side effects very rarely cause cessation of LLT. Urgent measures are needed to increase the awareness of FH among healthcare providers and patients and to develop improved treatment strategies aimed at preventing the complications of FH. (c) 2023 National Lipid Association. Published by Elsevier Inc. All rights reserved.

引用

页码：732 / 742

页数：11

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