The role of gastrin 17 and pepsinogen I:pepsinogen II ratio in pathological diagnosis and endoscopic selection in gastritis patients

被引:2
作者
Ye, Qian [1 ]
Xu, Kai [1 ]
Tong, Yu [1 ]
Zhao, Misheng [1 ]
机构
[1] Wenzhou Peoples Hosp, Dept Clin Lab, Wenzhou, Zhejiang, Peoples R China
关键词
gastritis; gastrin-17; pepsinogen I; pepsinogen II; colonoscopy; clinical pathology; AP gastrointestinal; HELICOBACTER-PYLORI INFECTION; SERUM PEPSINOGEN; ATROPHIC GASTRITIS; I/II RATIO; CANCER; BIOMARKERS; INFLAMMATION; ANTIBODY;
D O I
10.1093/labmed/lmad119
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: The noninvasive serum markers pepsinogen I (PGI), pepsinogen II (PGII), gastrin-17 (G17), and PGI:PGII ratio (PGR) have recently been proposed as a new tool for predicting various gastric pathologies. Methods: A total of 83 gastritis patients confirmed by gastroscopy were enrolled, with 78 undergoing concurrent colonoscopies. The control group included 99 healthy subjects. Enzyme-linked immunosorbent assay was used to detect PGI, PGII, G17, and PGR. The performance of serological analysis for detecting gastritis pathology was evaluated using receiver operating characteristic (ROC) curves. Results: The G17 and PGII levels increased significantly (P < .001), whereas PGR levels decreased (P = .001) in the gastritis group. The ROC analysis revealed that PGR had a sensitivity and specificity of 70.83% and 86.67%, respectively, in predicting Helicobacter pylori-infected gastritis and a sensitivity and specificity of 88% and 65.52%, respectively, in predicting active gastritis. The G17 levels were significantly elevated in gastritis patients undergoing concurrent colonoscopies (P < .05). Conclusion: Pepsinogen I:pepsinogen II ratio was found to be a useful predictor of active gastritis and H pylori-infected gastritis. Furthermore, G17 was found to be closely related to pathological conditions found by colonoscopy and may provide recommendations for whether gastritis patients should undergo a concurrent colonoscopy.
引用
收藏
页码:498 / 505
页数:8
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