Hemodialysis treatment of vancomycin-induced drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome in a patient undergoing peritoneal dialysis

被引:1
作者
Mitsuno, Ryunosuke [1 ,2 ]
Nakayama, Takashin [1 ]
Uchiyama, Kiyotaka [1 ]
Yoshimoto, Norifumi [1 ]
Kusahana, Ei [1 ]
Morimoto, Kohkichi [2 ]
Yoshino, Jun [1 ]
Yoshida, Tadashi [2 ]
Kanda, Takeshi [1 ]
Yamaguchi, Shintaro [1 ]
Hayashi, Kaori [1 ]
机构
[1] Keio Univ, Sch Med, Dept Internal Med, Div Endocrinol Metab & Nephrol, Tokyo 1608582, Japan
[2] Keio Univ, Sch Med, Apheresis & Dialysis Ctr, 35 Shinanomachi,Shinjuku Ku, Tokyo 1608582, Japan
关键词
Drug reaction with eosinophilia and systemic symptoms; Drug-induced hypersensitivity syndrome; Vancomycin; Dialysis; BLOOD PURIFICATION; DRESS SYNDROME;
D O I
10.1007/s13730-023-00847-x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe drug-induced hypersensitivity reaction with 10% mortality. To date, there is insufficient evidence regarding the association between DRESS/DIHS and serum levels of vancomycin (VCM). Here, we report the case of a 46-year-old woman undergoing peritoneal dialysis who developed VCM-induced DRESS/DIHS. She was hospitalized for peritonitis with abdominal pain and treated with VCM. On day 10 of hospitalization, her abdominal symptoms improved; however, fever, skin rash, lymphadenopathy, eosinophilia, atypical lymphocytes, and liver and renal dysfunction developed. Based on the clinical course and laboratory findings, we diagnosed the patient with DRESS/DIHS due to VCM. Since her serum VCM concentration was high at 39.8 mu g/mL, hemodialysis (HD) was performed to remove VCM, which caused her symptoms to improve. However, serum levels of VCM rebounded and the same symptoms recurred. Therefore, we re-performed HD; no further relapse occurred. This clinical course showed that increased serum VCM levels were associated with DRESS/DIHS onset and severity, suggesting that it is a blood level-dependent disease and that removal of VCM by HD is a potential therapeutic option.
引用
收藏
页码:339 / 345
页数:7
相关论文
共 24 条
[1]   Risk Factors for Vancomycin Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome [J].
Blumenthal, Kimberly G. ;
Alvarez-Arango, Santiago ;
Fu, Xiaoqing ;
Kroshinsky, Daniela ;
Choi, Hyon ;
Phillips, Elizabeth ;
Zhou, Li .
JAMA DERMATOLOGY, 2022, 158 (12) :1449-1453
[2]   Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS) [J].
Bocquet, H ;
Bagot, M ;
Roujeau, JC .
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY, 1996, 15 (04) :250-257
[3]  
BOHLER J, 1992, EUR J CLIN PHARMACOL, V42, P635
[4]   The DRESS Syndrome: A Literature Review [J].
Cacoub, Patrice ;
Musette, Philippe ;
Descamps, Vincent ;
Meyer, Olivier ;
Speirs, Chris ;
Finzi, Laetitia ;
Roujeau, Jean Claude .
AMERICAN JOURNAL OF MEDICINE, 2011, 124 (07) :588-597
[5]   Genetic Variants Associated With Phenytoin-Related Severe Cutaneous Adverse Reactions [J].
Chung, Wen-Hung ;
Chang, Wan-Chun ;
Lee, Yun-Shien ;
Wu, Ying-Ying ;
Yang, Chih-Hsun ;
Ho, Hsin-Chun ;
Chen, Ming-Jing ;
Lin, Jing-Yi ;
Hui, Rosaline Chung-Yee ;
Ho, Ji-Chen ;
Wu, Wei-Ming ;
Chen, Ting-Jui ;
Wu, Tony ;
Wu, Yih-Ru ;
Hsih, Mo-Song ;
Tu, Po-Hsun ;
Chang, Chen-Nen ;
Hsu, Chien-Ning ;
Wu, Tsu-Lan ;
Choon, Siew-Eng ;
Hsu, Chao-Kai ;
Chen, Der-Yuan ;
Liu, Chin-San ;
Lin, Ching-Yuang ;
Kaniwa, Nahoko ;
Saito, Yoshiro ;
Takahashi, Yukitoshi ;
Nakamura, Ryosuke ;
Azukizawa, Hiroaki ;
Shi, Yongyong ;
Wang, Tzu-Hao ;
Chuang, Shiow-Shuh ;
Tsai, Shih-Feng ;
Chang, Chee-Jen ;
Chang, Yu-Sun ;
Hung, Shuen-Iu .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2014, 312 (05) :525-534
[6]   Drug-Induced Hypersensitivity Syndrome (DIHS)/Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): Clinical Features and Pathogenesis [J].
Hama, Natsumi ;
Abe, Riichiro ;
Gibson, Andrew ;
Phillips, Elizabeth J. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2022, 10 (05) :1155-1168
[7]   A case of drug-induced hypersensitivity syndrome with multiple organ involvement treated with plasma exchange [J].
Higuchi, M ;
Agatsuma, T ;
Iizima, M ;
Yamazaki, Y ;
Saita, T ;
Ichikawa, T ;
Kamijo, Y ;
Arakura, H ;
Hora, K ;
Kiyosawa, K .
THERAPEUTIC APHERESIS AND DIALYSIS, 2005, 9 (05) :412-416
[8]   Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study [J].
Kardaun, S. H. ;
Sekula, P. ;
Valeyrie-Allanore, L. ;
Liss, Y. ;
Chu, C. Y. ;
Creamer, D. ;
Sidoroff, A. ;
Naldi, L. ;
Mockenhaupt, M. ;
Roujeau, J. C. .
BRITISH JOURNAL OF DERMATOLOGY, 2013, 169 (05) :1071-1080
[9]   Cyclosporine Treatment of Drug-Induced Hypersensitivity Syndrome [J].
Kirchhof, Mark G. ;
Wong, Aaron ;
Dutz, Jan P. .
JAMA DERMATOLOGY, 2016, 152 (11) :1254-1257
[10]  
Kishnani Priya S, 2014, Genet Med, V16, pe1