Liquid biopsy biomarkers to guide immunotherapy in breast cancer

被引：7

作者：

Yang, Jinghan ^{[1
]}

Qiu, Liang ^{[2
]}

Wang, Xi ^{[3
]}

Chen, Xi ^{[4
]}

Cao, Pingdong ^{[5
]}

Yang, Zhe ^{[5
]}

Wen, Qiang ^{[5
]}

机构：

[1] Vanderbilt Univ, Dept Biol Sci, Nashville, TN USA

[2] Stanford Univ, Dept Radiat Oncol, Palo Alto, CA USA

[3] Chinese Univ Hong Kong, Dept Comp Sci & Engn, Hong Kong, Peoples R China

[4] Shandong First Med Univ, Shandong Prov Hosp, Dept Human Resource, Jinan, Peoples R China

[5] Shandong First Med Univ, Shandong Prov Hosp, Dept Radiat Oncol, Jinan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

liquid biopsy; breast cancer; immunotherapy; immune checkpoint inhibitors; biomarkers; CIRCULATING TUMOR-CELLS; FREE DNA; PD-L1; EXPRESSION; ANTI-PD-L1; ANTIBODY; DENDRITIC CELLS; MUTATION BURDEN; OPEN-LABEL; PHASE-III; PEMBROLIZUMAB; CHEMOTHERAPY;

D O I：

10.3389/fimmu.2023.1303491

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune checkpoint inhibitors (ICIs) therapy has emerged as a promising treatment strategy for breast cancer (BC). However, current reliance on immunohistochemical (IHC) detection of PD-L1 expression alone has limited predictive capability, resulting in suboptimal efficacy of ICIs for some BC patients. Hence, developing novel predictive biomarkers is indispensable to enhance patient selection for immunotherapy. In this context, utilizing liquid biopsy (LB) can provide supplementary or alternative value to PD-L1 IHC testing for identifying patients most likely to benefit from immunotherapy and exhibit favorable responses. This review discusses the predictive and prognostic value of LB in breast cancer immunotherapy, as well as its limitations and future directions. We aim to promote the individualization and precision of immunotherapy in BC by elucidating the role of LB in clinical practice.

引用

页数：13

共 121 条

[1] Sequential Tracking of PD-L1 Expression and RAD50 Induction in Circulating Tumor and Stromal Cells of Lung Cancer Patients Undergoing Radiotherapy [J].

Adams, Daniel L. ;

Adams, Diane K. ;

He, Jianzhong ;

Kalhor, Neda ;

Zhang, Ming ;

Xu, Ting ;

Gao, Hui ;

Reuben, James M. ;

Qiao, Yawei ;

Komaki, Ritsuko ;

Liao, Zhongxing ;

Edelman, Martin J. ;

Tang, Cha-Mei ;

Lin, Steven H. .

CLINICAL CANCER RESEARCH, 2017, 23 (19) :5948-5958

[2]

Adams S, 2019, ANN ONCOL, V30, P397, DOI [10.1093/annonc/mdy517, 10.1093/annonc/mdy518]

[3] Role of the expression of PD-L1 and CD47 on circulating tumor cells (CTCs) in the prediction of outcome in metastatic breast cancer (mBC) patients. [J].

Agelaki, Sofia ;

Papadaki, Maria A. ;

Tsoulfas, Panormitis G. ;

Aggouraki, Despoina ;

Monastirioti, Alexia A. ;

Merodoulaki, Katerina A. ;

Thomopoulou, Konstantina ;

Papadaki, Chara ;

Mavroudis, Dimitrios .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)

[4] Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles [J].

Andreola, G ;

Rivoltini, L ;

Castelli, C ;

Huber, V ;

Perego, P ;

Deho, P ;

Squarcina, P ;

Accornero, P ;

Lozupone, F ;

Lugini, L ;

Stringaro, A ;

Molinari, A ;

Arancia, G ;

Gentile, M ;

Parmiani, G ;

Fais, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (10) :1303-1316

[5] Three-fold overestimation of tumor mutation burden using 248 gene panel versus whole exome. [J].

Andrew Nguyen ;

Garner, Chad ;

Reddy, Sandeep K. ;

Sanborn, John Z. ;

Benz, Stephen Charles ;

Seery, Tara Elisabeth ;

Rabizadeh, Shahrooz .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)

[6] PD-L1 expression is regulated by both DNA methylation and NF-κB during EMT signaling in non-small cell lung carcinoma [J].

Asgarova, A. ;

Asgarov, K. ;

Godet, Y. ;

Peixoto, P. ;

Nadaradjane, A. ;

Boyer-Guittaut, M. ;

Galaine, J. ;

Guenat, D. ;

Mougey, V. ;

Perrard, J. ;

Pallandre, J. R. ;

Bouard, A. ;

Balland, J. ;

Tirole, C. ;

Adotevi, O. ;

Hendrick, E. ;

Herfs, M. ;

Cartron, P. F. ;

Borg, C. ;

Hervouet, E. .

ONCOIMMUNOLOGY, 2018, 7 (05)

[7] Liquid Biopsies, What We Do Not Know (Yet) [J].

Bardelli, Alberto ;

Pantel, Klaus .

CANCER CELL, 2017, 31 (02) :172-179

[8] Prevalence and mutational determinants of high tumor mutation burden in breast cancer [J].

Barroso-Sousa, R. ;

Jain, E. ;

Cohen, O. ;

Kim, D. ;

Buendia-Buendia, J. ;

Winer, E. ;

Lin, N. ;

Tolaney, S. M. ;

Wagle, N. .

ANNALS OF ONCOLOGY, 2020, 31 (03) :387-394

[9] Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer [J].

Barroso-Sousa, Romualdo ;

Keenan, Tanya E. ;

Pernas, Sonia ;

Exman, Pedro ;

Jain, Esha ;

Garrido-Castro, Ana C. ;

Hughes, Melissa ;

Bychkovsky, Brittany ;

Umeton, Renato ;

Files, Janet L. ;

Lindeman, Neal I. ;

MacConaill, Laura E. ;

Hodi, F. Stephen ;

Krop, Ian E. ;

Dillon, Deborah ;

Winer, Eric P. ;

Wagle, Nikhil ;

Lin, Nancy U. ;

Mittendorf, Elizabeth A. ;

Van Allen, Eliezer M. ;

Tolaney, Sara M. .

CLINICAL CANCER RESEARCH, 2020, 26 (11) :2565-2572

[10] Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies [J].

Bettegowda, Chetan ;

Sausen, Mark ;

Leary, Rebecca J. ;

Kinde, Isaac ;

Wang, Yuxuan ;

Agrawal, Nishant ;

Bartlett, Bjarne R. ;

Wang, Hao ;

Luber, Brandon ;

Alani, Rhoda M. ;

Antonarakis, Emmanuel S. ;

Azad, Nilofer S. ;

Bardelli, Alberto ;

Brem, Henry ;

Cameron, John L. ;

Lee, Clarence C. ;

Fecher, Leslie A. ;

Gallia, Gary L. ;

Gibbs, Peter ;

Le, Dung ;

Giuntoli, Robert L. ;

Goggins, Michael ;

Hogarty, Michael D. ;

Holdhoff, Matthias ;

Hong, Seung-Mo ;

Jiao, Yuchen ;

Juhl, Hartmut H. ;

Kim, Jenny J. ;

Siravegna, Giulia ;

Laheru, Daniel A. ;

Lauricella, Calogero ;

Lim, Michael ;

Lipson, Evan J. ;

Marie, Suely Kazue Nagahashi ;

Netto, George J. ;

Oliner, Kelly S. ;

Olivi, Alessandro ;

Olsson, Louise ;

Riggins, Gregory J. ;

Sartore-Bianchi, Andrea ;

Schmidt, Kerstin ;

Shih, Ie-Ming ;

Oba-Shinjo, Sueli Mieko ;

Siena, Salvatore ;

Theodorescu, Dan ;

Tie, Jeanne ;

Harkins, Timothy T. ;

Veronese, Silvio ;

Wang, Tian-Li ;

Weingart, Jon D. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

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