Phyllofenones F-M, Scalarane Sesterterpenes from the Marine Sponge Phyllospongia foliascens

被引：2

作者：

Yu, Hao-Bing ^{[1
]}

Hu, Bo ^{[1
]}

Ning, Zhe ^{[1
]}

He, Ying ^{[1
]}

Men, Xiao-Ling ^{[1
,2
]}

Yin, Zi-Fei ^{[1
,3
]}

Jiao, Bing-Hua ^{[1
,4
]}

Liu, Xiao-Yu ^{[1
]}

Lin, Hou-Wen ^{[2
]}

机构：

[1] Naval Med Univ, Naval Med Ctr PLA, Dept Marine Biomed & Polar Med, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Res Ctr Marine Drugs, Sch Med, State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China

[3] Naval Med Univ, Sch Tradit Chinese Med, Shanghai 200433, Peoples R China

[4] Naval Med Univ, Coll Basic Med Sci, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China

来源：

MARINE DRUGS | 2023年 / 21卷 / 10期

基金：

上海市自然科学基金;

关键词：

scalarane; Phyllospongia foliascens; cytotoxicity; antibacterial activity; ALDOL REACTIONS;

D O I：

10.3390/md21100507

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight new scalarane sesterterpenes, phyllofenones F-M (1-8), together with two known analogues, carteriofenones B and A (9-10), were isolated from the marine sponge Phyllospongia foliascens collected from the South China Sea. The structures of these compounds were determined based on extensive spectroscopic and quantum chemical calculation analysis. The antibacterial and cytotoxic activity of these compounds was evaluated. Among them, only compounds 4 and 6 displayed weak inhibitory activity against Staphylococcus aureus and Escherichia coli, with MIC values of 16 mu g/mL and 8 mu g/mL, respectively. Compounds 1-10 exhibited cytotoxic activity against the HeLa, HCT-116, H460, and SW1990 cancer cell lines, with IC50 values ranging from 3.4 to 19.8 mu M.

引用

页数：14

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