Aligned Electroactive Electrospun Fibrous Scaffolds for Peripheral Nerve Regeneration

被引：28

作者：

Xiong, Feng ^{[1
]}

Wei, Shuo ^{[1
]}

Wu, Shuyuan ^{[1
]}

Jiang, Wei ^{[1
]}

Li, Biyun ^{[1
]}

Xuan, Hongyun ^{[1
]}

Xue, Ye ^{[1
]}

Yuan, Huihua ^{[1
]}

机构：

[1] Nantong Univ, Sch Life Sci, Nantong 226019, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2023年 / 15卷 / 35期

基金：

中国国家自然科学基金;

关键词：

piezoelectric; conductive; aligned electrospunfibrous; electroactive scaffold peripheral nerve regeneration; TRANSECTED SCIATIC-NERVE; SPINAL-CORD; CELLS; POLYPYRROLE; ADHESION; STIMULATION; FABRICATION; NANOFIBERS; FIELDS;

D O I：

10.1021/acsami.3c09237

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Effective repair and functional recovery of large peripheralnervedeficits are urgent clinical needs. A biofunctional electroactivescaffold typically acts as a "bridge" for the repairof large nerve defects. In this study, we constructed a biomimeticpiezoelectric and conductive aligned polypyrrole (PPy)/polydopamine(PDA)/poly-l-lactic acid (PLLA) electrospun fibrous scaffoldto improve the hydrophilicity and cellular compatibility of PLLA andrestore the weakened piezoelectric effect of PDA, which is beneficialin promoting Schwann cell differentiation and dorsal root ganglionneuronal extension and alignment. The aligned PPy/PDA/PLLA fibrousscaffold bridged the sciatic nerve of Sprague-Dawley rats witha 10 mm deficit, prevented autotomy, and promoted nerve regenerationand functional recovery, thereby activating the calcium and AMP-activatedprotein kinase signaling pathways. Therefore, electroactive fibrousscaffolds exhibit great potential for neural tissue regeneration.

引用

页码：41385 / 41402

页数：18

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