LVAD therapy as a catalyst to heart failure remission and myocardial recovery

被引：7

作者：

Hamad, Eman A. ^{[1
]}

Byku, Mirnela ^{[2
]}

Larson, Sharon B. ^{[3
]}

Billia, Filio ^{[4
]}

机构：

[1] Temple Univ, Lewis Katz Sch Med, 3401 N Broad St, 9th Floor Parkinson, Zone C, Philadelphia, PA 19140 USA

[2] Univ North Carolina, Dept Med, Chapel Hill, NC USA

[3] Baptist Heart Inst Baptist Mem Hosp, Memphis, TN USA

[4] Univ Hlth Network, Peter Munk Cardiac Ctr, Toronto, ON, Canada

来源：

CLINICAL CARDIOLOGY | 2023年 / 46卷 / 10期

关键词：

explant; GDMT; LVAD; recovery; VENTRICULAR ASSIST DEVICE; VALVE REGURGITATION; SURGICAL APPROACH; SUCCESSFUL BRIDGE; EXPLANTATION; REMOVAL; SUPPORT; CARDIOMYOPATHY; IMPROVEMENT; MANAGEMENT;

D O I：

10.1002/clc.24094

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The management of chronic heart failure over the past decade has witnessed tremendous strides in medical optimization and device therapy including the use of left ventricular assist devices (LVAD). What we once thought of as irreversible damage to the myocardium is now demonstrating signs of reverse remodeling and recovery. Myocardial recovery on the structural, molecular, and hemodynamic level is necessary for sufficient recovery to withstand explant and achieve sustained recovery post-LVAD. Guideline-directed medical therapy and unloading have been shown to aid in recovery with the potential to successfully explant the LVAD. This review will summarize medical optimization, assessment for recovery, explant methodologies and outcomes post-recovery with explant of durable LVAD.

引用

页码：1154 / 1162

页数：9

共 50 条

[41] Clinical myocardial recovery during long-term mechanical support in advanced heart failure: Insights into moving the field forward [J].

Drakos, Stavros G. ;

Mehra, Mandeep R. .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2016, 35 (04) :413-420

[42] Alternatives to transplantation in the surgical therapy for heart failure [J].

Nicolini, Francesco ;

Gherli, Tiziano .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2009, 35 (02) :214-228

[43] Predictive power of late gadolinium enhancement for myocardial recovery in chronic ischaemic heart failure: a HEART sub-study [J].

McDiarmid, Adam K. ;

Loh, Huan ;

Nikitin, Nikolay ;

Cleland, John G. ;

Ball, Stephen G. ;

Greenwood, John P. ;

Plein, Sven ;

Sparrow, Patrick .

ESC HEART FAILURE, 2014, 1 (02) :146-153

[44] Predicting Benefit From Revascularization in Patients With Ischemic Heart Failure Imaging of Myocardial Ischemia and Viability [J].

Buckley, Orla ;

Di Carli, Marcelo .

CIRCULATION, 2011, 123 (04) :444-450

[45] Computational modelling of myocardial metabolism in patients with advanced heart failure [J].

Beyhoff, Niklas ;

Braun, Vera M. ;

Kirchner, Marieluise ;

Finnigan, Lucy E. M. ;

Knosalla, Christoph ;

Baczko, Istvan ;

Potapov, Evgenij ;

Kintscher, Ulrich ;

Grune, Tilman ;

Kuehne, Titus ;

Holzhuetter, Hermann-Georg ;

Mertins, Philipp ;

Tyler, Damian J. ;

Milting, Hendrik ;

Raman, Betty ;

Rider, Oliver J. ;

Neubauer, Stefan ;

Berndt, Nikolaus .

EUROPEAN JOURNAL OF HEART FAILURE, 2025,

[46] Evolution of Myocardial Dysfunction in Asymptomatic Patients at Risk of Heart Failure [J].

Halabi, Amera ;

Yang, Hilda ;

Wright, Leah ;

Potter, Elizabeth ;

Quan Huynh ;

Negishi, Kazuaki ;

Marwick, Thomas H. .

JACC-CARDIOVASCULAR IMAGING, 2021, 14 (02) :350-361

[47] Distinct Myocardial Targets for Diabetes Therapy in Heart Failure With Preserved or Reduced Ejection Fraction [J].

Paulus, Walter J. ;

Dal Canto, Elisa .

JACC-HEART FAILURE, 2018, 6 (01) :1-7

[48] Surgical Device Therapy for Heart Failure in the Adult with Congenital Heart Disease [J].

Mulukutla, Venkatachalam ;

Franklin, Wayne J. ;

Villa, Chet R. ;

Morales, David Luis Simon .

HEART FAILURE CLINICS, 2014, 10 (01) :197-+

[49] Destination LVAD therapy in the current era of the heart transplant allocation system [J].

Toro, Saleem ;

Patel, Kelsey ;

Guha, Ashrith .

CURRENT OPINION IN CARDIOLOGY, 2023, 38 (03) :275-279

[50] Hemodynamic reserve predicts early right heart failure after LVAD implantation [J].

Read, Jacob M. ;

Azih, Nnamdi, I ;

Peters, Carli J. ;

Gurtu, Vikram ;

Vishram-Nielsen, Julie K. ;

Wright, Stephen P. ;

Alba, Ana Carolina ;

Gregoski, Mathew J. ;

Pilch, Nicole A. ;

Hsu, Steven ;

Genuardi, Michael, V ;

Inampudi, Chakradhari ;

Jackson, Gregory R. ;

Pope, Nicholas ;

Witer, Lucas P. ;

Kilic, Arman ;

Houston, Brian A. ;

Mak, Susanna ;

Birati, Edo Y. ;

Tedford, Ryan J. .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2022, 41 (12) :1716-1726

← 1 2 3 4 5 →