LVAD therapy as a catalyst to heart failure remission and myocardial recovery

被引：7

作者：

Hamad, Eman A. ^{[1
]}

Byku, Mirnela ^{[2
]}

Larson, Sharon B. ^{[3
]}

Billia, Filio ^{[4
]}

机构：

[1] Temple Univ, Lewis Katz Sch Med, 3401 N Broad St, 9th Floor Parkinson, Zone C, Philadelphia, PA 19140 USA

[2] Univ North Carolina, Dept Med, Chapel Hill, NC USA

[3] Baptist Heart Inst Baptist Mem Hosp, Memphis, TN USA

[4] Univ Hlth Network, Peter Munk Cardiac Ctr, Toronto, ON, Canada

来源：

CLINICAL CARDIOLOGY | 2023年 / 46卷 / 10期

关键词：

explant; GDMT; LVAD; recovery; VENTRICULAR ASSIST DEVICE; VALVE REGURGITATION; SURGICAL APPROACH; SUCCESSFUL BRIDGE; EXPLANTATION; REMOVAL; SUPPORT; CARDIOMYOPATHY; IMPROVEMENT; MANAGEMENT;

D O I：

10.1002/clc.24094

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The management of chronic heart failure over the past decade has witnessed tremendous strides in medical optimization and device therapy including the use of left ventricular assist devices (LVAD). What we once thought of as irreversible damage to the myocardium is now demonstrating signs of reverse remodeling and recovery. Myocardial recovery on the structural, molecular, and hemodynamic level is necessary for sufficient recovery to withstand explant and achieve sustained recovery post-LVAD. Guideline-directed medical therapy and unloading have been shown to aid in recovery with the potential to successfully explant the LVAD. This review will summarize medical optimization, assessment for recovery, explant methodologies and outcomes post-recovery with explant of durable LVAD.

引用

页码：1154 / 1162

页数：9

共 50 条

[21] Clinical myocardial recovery in advanced heart failure with long term left ventricular assist device support [J].

Kanwar, Manreet K. ;

Selzman, Craig H. ;

Ton, Van-Khue ;

Miera, Oliver ;

Cornwell, William K. ;

Antaki, James ;

Drakos, Stavros ;

Shah, Palak .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2022, 41 (10) :1324-1334

[22] Building a bridge to recovery: the pathophysiology of LVAD-induced reverse modeling in heart failure [J].

Miyagawa, Shigeru ;

Toda, Koichi ;

Nakamura, Teruya ;

Yoshikawa, Yasushi ;

Fukushima, Satsuki ;

Saito, Shunsuke ;

Yoshioka, Daisuke ;

Saito, Tetsuya ;

Sawa, Yoshiki .

SURGERY TODAY, 2016, 46 (02) :149-154

[23] Palliative Therapy in Heart Failure [J].

Hritz, Christopher M. .

HEART FAILURE CLINICS, 2018, 14 (04) :617-+

[24] Analysis of Metabolic Markers in Patients with Chronic Heart Failure before and after LVAD Implantation [J].

Hilse, Marion S. ;

Kretzschmar, Tom ;

Pistulli, Rudin ;

Franz, Marcus ;

Bekfani, Tarek ;

Haase, Daniela ;

Neugebauer, Sophie ;

Kiehntopf, Michael ;

Gummert, Jan F. ;

Milting, Hendrik ;

Schulze, P. Christian .

METABOLITES, 2021, 11 (09)

[25] Impact of Ischemic Heart Failure Etiology on Cardiac Recovery During Mechanical Unloading [J].

Wever-Pinzon, James ;

Selzman, Craig H. ;

Stoddard, Greg ;

Wever-Pinzon, Omar ;

Catino, Anna ;

Kfoury, Abdallah G. ;

Diakos, Nikolaos A. ;

Reid, Bruce B. ;

McKellar, Stephen ;

Bonios, Michael ;

Koliopoulou, Antigone ;

Budge, Deborah ;

Kelkhoff, Aaron ;

Stehlik, Josef ;

Fang, James C. ;

Drakos, Stavros G. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 68 (16) :1741-1752

[26] Life-Prolonging Benefits of LVAD Therapy in Advanced Heart Failure A Clinician's Action and Communication Aid [J].

Mehra, Mandeep R. ;

Nayak, Aditi ;

Desai, Akshay S. .

JACC-HEART FAILURE, 2023, 11 (08) :1011-1017

[27] Predictably disappointing: Modeling risk of right heart failure in LVAD recipients [J].

Gulati, Gaurav ;

Kiernan, Michael S. .

EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, 2021, 10 (07) :733-735

[28] LVAD decommissioning for myocardial recovery: Long-term ventricular remodeling and adverse events [J].

Gerhard, Eleanor F. ;

Wang, Lu ;

Singh, Ramesh ;

Schueler, Stephan ;

Genovese, Leonard D. ;

Woods, Andrew ;

Tang, Daniel ;

Smith, Nicola Robinson ;

Psotka, Mitchell A. ;

Tovey, Sian ;

Desai, Shashank S. ;

Jakovljevic, Djordje G. ;

MacGowan, Guy A. ;

Shah, Palak .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2021, 40 (12) :1560-1570

[29] Parameters of repolarization heterogeneity are associated with myocardial recovery in acute heart failure [J].

Prenner, Stuart B. ;

Swat, Stanley A. ;

Ng, Jason ;

Baldridge, Abigail ;

Wilcox, Jane E. .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2020, 301 :147-151

[30] Mechanical Unloading Promotes Myocardial Energy Recovery in Human Heart Failure [J].

Gupte, Anisha A. ;

Hamilton, Dale J. ;

Cordero-Reyes, Andrea M. ;

Youker, Keith A. ;

Yin, Zheng ;

Estep, Jerry D. ;

Stevens, Robert D. ;

Wenner, Brett ;

Ilkayeva, Olga ;

Loebe, Matthias ;

Peterson, Leif E. ;

Lyon, Christopher J. ;

Wong, Stephen T. C. ;

Newgard, Christopher B. ;

Torre-Amione, Guillermo ;

Taegtmeyer, Heinrich ;

Hsueh, Willa A. .

CIRCULATION-CARDIOVASCULAR GENETICS, 2014, 7 (03) :266-276

← 1 2 3 4 5 →