Autoimmune bullous diseases in pregnancy: an overview of pathogenesis, clinical presentations, diagnostics and available therapies

被引:7
作者
Vicic, Marijana [1 ]
Marinovic, Branka [2 ,3 ]
机构
[1] Univ Rijeka, Clin Hosp Ctr Rijeka, Fac Med, Dept Dermatovenereol, Rijeka, Croatia
[2] Univ Zagreb, Univ Hosp Ctr Zagreb, Fac Med, Dept Dermatovenereol, Zagreb, Croatia
[3] Univ Zagreb, Univ Hosp Ctr Zagreb, Fac Med, Dept Dermatovenereol, Kispaticeva 12, Zagreb 10000, Croatia
关键词
Autoimmunity; Skin Diseases; vesiculobullous; Pemphigoid gestationis; Pemphigus; Pregnancy; REGULATORY T-CELLS; PEMPHIGOID GESTATIONIS; HERPES-GESTATIONIS; BLISTERING DISEASE; BP180; ANTIGEN; SKIN; MANAGEMENT; FEATURES; ASSOCIATION; MECHANISMS;
D O I
10.23736/S2784-8671.23.07553-9
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Autoimmune bullous diseases (AIBDs) are rare organ-specific diseases characterized by the appearance of blisters and erosions on the skin and mucous membranes. These dermatoses are marked by the development of autoantibodies targeting the autoantigens located in intercellular junctions, i.e., between keratinocytes or in the basement membrane area. Therefore, the fundamental division of AIBDs into the pemphigus and pemphigoid groups exists. Although AIBDs are uncommon in the general population, their overall incidence is somewhat higher in women of all ages, for which a pregnant women can be likely affected too. While the pemphigoid gestationis is exclusive bullous dermatosis of pregnancy, the other AIBDs can also start or worsen during this period. The appearance of AIBDs in childbearing women is a particularly sensitive situation requiring exceptional clinicians' caution due to the possibility of pregnancy complications with adverse effects and risks to the mother and the child. Also, there are numerous management difficulties in the period of pregnancy and lactation related to the drugs' choice and safety. This paper aimed to outline the pathophysiologic mechanisms, clinical manifestations, diagnostic approach and therapy of the most commonly recognized AIBDs in pregnancy.
引用
收藏
页码:99 / 109
页数:11
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