In this paper, we revisit the discussion on integrating indigenous world-views with 'Western science and practice' towards collective futures (Mazzocchi et al., 2018), especially in the continuing aftermath of the COVID-19 pandemic. Acknowledging the serious work required to attempt such integration and its direct necessity for human and trans-human futures, we review the two fundamentally distinct world-views and their resultant concomitant implications for human development, with specific reference to environment and biodiversity. To that end, we have first identified key assumptions and practical implications of Indian philosophical frameworks and have selected one indigenous world-view that is quite popular - the yoga-samkhya world-view (Bhawuk, 2010), which we compare with the contemporary mainstream world-view of health and development. The Euro-American view, which is considered mainstream, is predominantly a market-based capitalist world-view. This framework has created a crisis of faith in contemporary times, especially with reference to sustainable development, climate change and health (Iseke-Barnes & Danard, 2006), resulting in disruptions and churning in thought processes across political, economic and social systems. The two world-views that we compare, suggesting an integration, is a preliminary work in line with the earlier work by Bussey and Inayatullah, but is specific towards the yoga-samkhya perspective, which is indigenous Indian view. Integration of an indigenous world-view foregrounds the possibility of three different futures of human development. COVID 19 provides us with that historical moment of introspection towards a more sustainable future that structurally integrates an indigenous perspective with contemporary perspectives of human development and health.