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Polymer translocation in an environment of active rods
被引:1
|作者:
Khalilian, Hamidreza
[1
]
Sarabadani, Jalal
[1
]
Ala-Nissila, Tapio
[2
,3
,4
,5
]
机构:
[1] Inst Res Fundamental Sci IPM, Sch Nano Sci, Tehran 193955531, Iran
[2] Aalto Univ, Dept Appl Phys, POB 11000, FI-00076 Espoo, Finland
[3] Aalto Univ, QTF Ctr Excellence, POB 11000, FI-00076 Espoo, Finland
[4] Loughborough Univ, Interdisciplinary Ctr Math Modelling, Loughborough LE11 3TU, Leics, England
[5] Loughborough Univ, Dept Math Sci, Loughborough LE11 3TU, Leics, England
来源:
PHYSICAL REVIEW RESEARCH
|
2023年
/
5卷
/
02期
基金:
芬兰科学院;
关键词:
ELECTROPHORETIC FORCE;
DNA;
NANOPORE;
DECADES;
D O I:
10.1103/PhysRevResearch.5.023107
中图分类号:
O4 [物理学];
学科分类号:
0702 ;
摘要:
We consider the dynamics of a translocation process of a flexible linear polymer through a nanopore into an environment of active rods in the trans side. Using Langevin dynamics simulations, we show that the rods facilitate translocation to the trans side even when there are initially more monomers on the cis than on the trans side. Structural analysis of the translocating polymer reveals that active rods induce a folded structure to the trans-side subchain in the case of successful translocation events. By keeping the initial number of monomers on the cis-side subchain fixed, we map out a state diagram for successful events as a function of the rod number density for a variety of system parameters. This reveals competition between facilitation by the rods at low densities and crowding that hinders translocation at higher densities.
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页数:10
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