Blocking huntingtin oligomers from binding lipid membranes improves phenotype in a C. elegans model of Huntington's disease

被引:0
|
作者
Siriwardhana, Chathuranga [1 ]
Legleiter, Justin A. [1 ]
机构
[1] West Virginia Univ, Dept Chem, Morgantown, WV USA
关键词
D O I
暂无
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
1650-Pos
引用
收藏
页码:338A / 339A
页数:2
相关论文
共 50 条
  • [1] Factors Modulating the Interaction of Huntingtin with Lipid Membranes: Implications for Huntington's Disease
    Legleiter, Justin
    Arndt, James R.
    Chaibva, Maxmore
    Gao, Xiang
    Jain, Pranav
    Sarver, Olivia
    Valentine, Stephen
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 358A - 359A
  • [2] Probing the morphological and mechanical changes in a C. elegans model of Huntington's disease
    Ellis, Zachary L.
    Siriwardhana, Chathuranga C.
    Legleiter, Justin A.
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 349A - 350A
  • [4] Dietary Restriction and Pioglitazone Protect against Proteotoxicity in a C. elegans model of Huntington's Disease
    Ekasumara, N.
    Marcellino, B. K.
    Mobbs, C.
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2013, 61 : S2 - S2
  • [5] Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model
    Wang, WF
    Duan, WZ
    Igarashi, S
    Morita, H
    Nakamura, M
    Ross, CA
    NEUROBIOLOGY OF DISEASE, 2005, 20 (02) : 500 - 508
  • [6] Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans
    Perni, Michele
    Mannini, Benedetta
    Xu, Catherine K.
    Kumita, Janet R.
    Dobson, Christopher M.
    Chiti, Fabrizio
    Vendruscolo, Michele
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [7] Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans
    Michele Perni
    Benedetta Mannini
    Catherine K. Xu
    Janet R. Kumita
    Christopher M. Dobson
    Fabrizio Chiti
    Michele Vendruscolo
    Scientific Reports, 11
  • [8] Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington's Disease
    Machiela, Emily
    Rudich, Paige D.
    Traa, Annika
    Anglas, Ulrich
    Soo, Sonja K.
    Senchuk, Megan M.
    Raamsdonk, Jeremy M. Van
    AGING AND DISEASE, 2021, 12 (07): : 1753 - 1772
  • [9] Label-free photothermal disruption of cytotoxic aggregates rescues pathology in a C. elegans model of Huntington's disease
    Nedosekin, Dmitry A.
    Chen, TsungYen
    Ayyadevara, Srinivas
    Zharov, Vladimir P.
    Shmookler Reis, Robert J.
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [10] Label-free photothermal disruption of cytotoxic aggregates rescues pathology in a C. elegans model of Huntington’s disease
    Dmitry A. Nedosekin
    TsungYen Chen
    Srinivas Ayyadevara
    Vladimir P. Zharov
    Robert J. Shmookler Reis
    Scientific Reports, 11