Degenerative Disorder of the Temporomandibular Joint Treated With Autologous Bone Marrow-Derived Stem Cells Using the Regentime Technique: A Case Report

被引:2
作者
Boulos, Rita T. [1 ]
Najjoum, Cynthia F. [2 ]
Asmar, Elsa A. El [3 ]
Chahine, Nassim H. Abi [4 ]
机构
[1] ACE Cells Lab UK Ltd, Stem Cell Transplantat Neurol, Sheffield Rotherham, Germany
[2] ACE Cells Lab UK Ltd, Stem Cell Transplantat Infect Dis Immunol, Sheffield Rotherham, Germany
[3] ACE Cells Lab UK Ltd, Stem Cell Transplantat Funct Genom Prote, Sheffield Rotherham, Germany
[4] ACE Cells Lab UK Ltd, Stem Cell Transplantat Neurol Surg, Sheffield Rotherham, Germany
关键词
tmj disorders; bone marrow -derived stem cells; autologous mononuclear stem cells; stem cell therapy; regentime therapy; temporomandibular joint degeneration; OSTEOARTHRITIS; DISPLACEMENT;
D O I
10.7759/cureus.34092
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Temporomandibular joint (TMJ) disease is a type of degenerative musculoskeletal disorder that leads to morphological and functional abnormalities. It has a poorly understood progression with numerous independent and interrelated factors, which makes it difficult for the available treatment options to meet long-term demands. We present the case of a 37-year-old woman who suffered from excruciating pain in the right temporomandibular joint, associated with limited mandibular movement. She was found to have imaging features of TMJ disorder. She underwent the Regentime procedure which uses autologous bone marrow -derived stem cells that are partially differentiated and redirected to the targeted tissue. Clinical follow-up showed total clinical recovery.
引用
收藏
页数:5
相关论文
共 16 条
[1]  
Buescher JJ, 2007, AM FAM PHYSICIAN, V76, P1477
[2]   Effect of in vitro chondrogenic differentiation of autologous mesenchymal stem cells on cartilage and subchondral cancellous bone repair in osteoarthritis of temporomandibular joint [J].
Chen, K. ;
Man, C. ;
Zhang, B. ;
Hu, J. ;
Zhu, S-S .
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2013, 42 (02) :240-248
[3]   Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis [J].
Cui, Dixin ;
Li, Hongyu ;
Xu, Xin ;
Ye, Ling ;
Zhou, Xuedong ;
Zheng, Liwei ;
Zhou, Yachuan .
STEM CELLS INTERNATIONAL, 2017, 2017
[4]   Bone marrow nucleated cell concentrate autograft in temporomandibular joint degenerative disorders: 1-year results of a randomized clinical trial [J].
De Riu, Giacomo ;
Vaira, Luigi Angelo ;
Carta, Elena ;
Meloni, Silvio Mario ;
Sembronio, Salvatore ;
Robiony, Massimo .
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 2019, 47 (11) :1728-1738
[5]   Evaluation of temporomandibular joint disc displacement as a risk factor for osteoarthrosis [J].
Dias, I. M. ;
Cordeiro, P. C. de F. ;
Devito, K. L. ;
Tavares, M. L. F. ;
Leite, I. C. G. ;
Tesch, R. de S. .
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2016, 45 (03) :313-317
[6]   Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives [J].
Harrell, C. Randall ;
Markovic, Bojana Simovic ;
Fellabaum, Crissy ;
Arsenijevic, Aleksandar ;
Volarevic, Vladislav .
BIOMEDICINE & PHARMACOTHERAPY, 2019, 109 :2318-2326
[7]   Correlations between the Helkimo indices and the maximal mandibular excursion capacities of patients with temporomandibular joint disorders [J].
Leamari, Victor Moreira ;
Rodrigues, Alex de Freitas ;
Camino Junior, Rubens ;
Luz, Joao Gualberto C. .
JOURNAL OF BODYWORK AND MOVEMENT THERAPIES, 2019, 23 (01) :148-152
[8]   Temporomandibular dysfunction [J].
Lomas, Jonathan ;
Gurgenci, Taylan ;
Jackson, Christopher ;
Campbell, Duncan .
AUSTRALIAN JOURNAL OF GENERAL PRACTICE, 2018, 47 (04) :212-215
[9]   Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-α [J].
Murakami, S ;
Lefebvre, V ;
de Crombrugghe, B .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (05) :3687-3692
[10]   Temporomandibular Disorders: A Review of Etiology, Clinical Management, and Tissue Engineering Strategies [J].
Murphy, Meghan K. ;
MacBarb, Regina F. ;
Wong, Mark E. ;
Athanasiou, Kyriacos A. .
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS, 2013, 28 (06) :E393-E414