Synthesis of Complex Dihydroisoquinolin Derivatives via Cobalt-Electrocatalyzed C-H Activation

We developed a cost-effective cobalt-catalyzed electrochemical annulation to generate diversified novel complex dihydroisoquinolin derivatives from amides and alkenes in a simple and maneuverable undivided cell. The reaction proceeded C-H/N-H activation, and the catalyst was regenerated by anodic oxidation. Notably, the strategy of electrocatalysis avoided the consumption of stoichiometric chemical oxidants.