Synthesis of Complex Dihydroisoquinolin Derivatives via Cobalt-Electrocatalyzed C-H Activation

被引：4

作者：

Huang, Yin-Hui ^{[1
,2
]}

Dong, Lin ^{[1
,2
]}

机构：

[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist & Sichuan Prov, Sichuan Engn Lab Plant Sourced Drug, Chengdu 610041, Peoples R China

[2] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 01期

关键词：

C-H bond activation; cobalt catalyst; electrochemistry; 4+2] annulation; dihydroisoquinolin; LATE-STAGE DIVERSIFICATION; RAPID CONSTRUCTION; 4+2 ANNULATION; SELECTIVITY; CATALYSIS; METALLAELECTROCATALYSIS; FUNCTIONALIZATION; ELECTROCHEMISTRY; CARBONYLATION; OLEFINATION;

D O I：

10.1002/adsc.202201155

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We developed a cost-effective cobalt-catalyzed electrochemical annulation to generate diversified novel complex dihydroisoquinolin derivatives from amides and alkenes in a simple and maneuverable undivided cell. The reaction proceeded C-H/N-H activation, and the catalyst was regenerated by anodic oxidation. Notably, the strategy of electrocatalysis avoided the consumption of stoichiometric chemical oxidants.

引用

页码：23 / 30

页数：8

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