Partial agonists of dopamine receptors: receptor theory and the dopamine hypothesis of psychosis

被引：4

作者：

Cookson, John ^{[1
,2
]}

Pimm, Jonathan ^{[3
]}

机构：

[1] East London NHS Fdn Trust, Royal London Hosp, London, England

[2] East London NHS Fdn Trust, Mile End Hosp, Tower Hamlets Ctr Mental Hlth, London, England

[3] East London NHS Fdn Trust, London, England

来源：

BJPSYCH ADVANCES | 2023年 / 29卷 / 02期

关键词：

Dopamine receptor partial agonist; aripiprazole; cariprazine; antipsychotics; polypharmacy; OCCUPANCY;

D O I：

10.1192/bja.2021.39

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This article discusses dopamine partial agonism, which is the main mechanism of action of the psychiatric drugs aripiprazole, brexpiprazole and cariprazine. It outlines the principles of receptor theory and the structure of dopamine receptors; characterises agonists, antagonists and partial agonists; and summarises the dopamine hypothesis of psychosis and the role of dopamine and serotonin in depression.

引用

页码：141 / 144

页数：4