Partial agonists of dopamine receptors: receptor theory and the dopamine hypothesis of psychosis

被引：4

作者：

Cookson, John ^{[1
,2
]}

Pimm, Jonathan ^{[3
]}

机构：

[1] East London NHS Fdn Trust, Royal London Hosp, London, England

[2] East London NHS Fdn Trust, Mile End Hosp, Tower Hamlets Ctr Mental Hlth, London, England

[3] East London NHS Fdn Trust, London, England

来源：

BJPSYCH ADVANCES | 2023年 / 29卷 / 02期

关键词：

Dopamine receptor partial agonist; aripiprazole; cariprazine; antipsychotics; polypharmacy; OCCUPANCY;

D O I：

10.1192/bja.2021.39

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This article discusses dopamine partial agonism, which is the main mechanism of action of the psychiatric drugs aripiprazole, brexpiprazole and cariprazine. It outlines the principles of receptor theory and the structure of dopamine receptors; characterises agonists, antagonists and partial agonists; and summarises the dopamine hypothesis of psychosis and the role of dopamine and serotonin in depression.

引用

页码：141 / 144

页数：4

共 12 条

[1] Dopamine System Dysregulation in Major Depressive Disorders [J].

Belujon, Pauline ;

Grace, Anthony A. .

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2017, 20 (12) :1036-1046

[2]

Boghog, 2014, INV AG

[3] Acute mania: Haloperidol dose and augmentation with lithium or lorazepam [J].

Chou, JCY ;

Czobor, P ;

Charles, O ;

Tuma, I ;

Winsberg, B ;

Allen, MH ;

Trujillo, M ;

Volavka, J .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 1999, 19 (06) :500-505

[4] Partial agonists of dopamine receptors: receptor theory and the dopamine hypothesis of psychosis [J].

Cookson, John ;

Pimm, Jonathan .

BJPSYCH ADVANCES, 2023, 29 (02) :141-144

[5]

FARDE L, 1992, ARCH GEN PSYCHIAT, V49, P538

[6] Adaptive mechanisms following antidepressant drugs: Focus on serotonin 5-HT2A receptors [J].

Gawlinski, Dawid ;

Smaga, Irena ;

Zaniewska, Magdalena ;

Gawlinska, Kinga ;

Faron-Gorecka, Agata ;

Filip, Malgorzata .

PHARMACOLOGICAL REPORTS, 2019, 71 (06) :994-1000

[7] Relationship between dopamine D2 occupancy, clinical response, and side effects:: A double-blind PET study of first-episode schizophrenia [J].

Kapur, S ;

Zipursky, R ;

Jones, C ;

Remington, G ;

Houle, S .

AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (04) :514-520

[8]

Kenakin T, 2019, HANDB EXP PHARMACOL, V260, P17, DOI 10.1007/164_2019_297

[9] Model-Guided Antipsychotic Dose Reduction in Schizophrenia A Pilot, Single-Blind Randomized Controlled Trial [J].

Ozawa, Chisa ;

Bies, Robert R. ;

Pillai, Nikhil ;

Suzuki, Takefumi ;

Mimura, Masaru ;

Uchida, Hiroyuki .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2019, 39 (04) :329-335

[10] Striatal dopamine D2/3 receptor-mediated neurotransmission in major depression: Implications for anhedonia, anxiety and treatment response [J].

Pecina, Marta ;

Sikora, Magdalena ;

Avery, Erich T. ;

Heffernan, Joseph ;

Pecina, Susana ;

Mickey, Brian J. ;

Zubieta, Jon-Kar .

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2017, 27 (10) :977-986

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