CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma

被引：13

作者：

Cao, Shi-qiang ^{[1
,2
]}

Xue, Song-tao ^{[1
,2
]}

Li, Wen-juan ^{[1
,2
]}

Hu, Guo-sheng ^{[3
,4
,5
]}

Wu, Zhi-gang ^{[1
,2
]}

Zheng, Jian-cong ^{[1
,2
]}

Zhang, Shu-liang ^{[1
,2
]}

Lin, Xiao ^{[1
,2
]}

Chen, Chun ^{[1
,2
]}

Liu, Wen ^{[3
,4
,5
]}

Zheng, Bin ^{[1
,2
]}

机构：

[1] Fujian Med Univ, Union Hosp, Dept Thorac Surg, 29 Xinquan Rd, Fuzhou 350001, Fujian, Peoples R China

[2] Fujian Med Univ, Fujian Key Lab Cardiothorac Surg, 29 Xinquan Rd, Fuzhou 350001, Fujian, Peoples R China

[3] Xiamen Univ, Fac Med & Life Sci, Sch Pharmaceut Sci, State Key Lab Cellular Stress Biol, Xiangan South Rd, Xiamen 361102, Fujian, Peoples R China

[4] Xiamen Univ, Fac Med & Life Sci, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiangan South Rd, Xiamen 361102, Fujian, Peoples R China

[5] Xiamen Univ, Fac Med & Life Sci, Sch Pharmaceut Sci, Xiang Biomed Lab, Xiangan South Rd, Xiamen 361102, Fujian, Peoples R China

来源：

CELL DEATH DISCOVERY | 2024年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

CIRCULAR RNA; ANTISENSE OLIGONUCLEOTIDES; SYNTHASE EXPRESSION; CANCER; PROLIFERATION; BIOGENESIS;

D O I：

10.1038/s41420-024-01881-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The oncogenic role of circRNA in cancers including esophageal cancer (EC) has been well studied. However, whether and how circRNAs are involved in cancer cell metabolic processes remains largely unknown. Here, we reported that circRNA, circHIPK3, is highly expressed in ESCC cell lines and tissues. Knockdown of circHIPK3 significantly restrained cell proliferation, colony formation, migration, and invasion in vitro and inhibited tumor growth in vivo. Mechanistically, circHIPK3 was found to act as a ceRNA by sponging miR-637 to regulate FASN expression and fatty acid metabolism in ESCC cells. Anti-sense oligonucleotide (ASO) targeting circHIPK3 substantially inhibited ESCC both in vitro and in vivo. Therefore, these results uncover a modulatory axis constituting of circHIPK3/miR-637/FASN may be a potential biomarker and therapeutic target for ESCC in the clinic.

引用

页数：13