Reproducibility of diffusion-weighted magnetic resonance imaging in head and neck cancer assessed on a 1.5 T MR-Linac and comparison to parallel measurements on a 3 T diagnostic scanner

被引:1
作者
Habrich, Jonas [1 ,9 ]
Boeke, Simon [2 ,3 ,4 ]
Fritz, Victor [5 ]
Koerner, Elisa [1 ]
Nikolaou, Konstantin [6 ]
Schick, Fritz [5 ]
Gani, Cihan [4 ]
Zips, Daniel [2 ,3 ,4 ,7 ,8 ]
Thorwarth, Daniela [1 ,2 ,3 ]
机构
[1] Univ Hosp Tubingen, Dept Radiat Oncol, Sect Biomed Phys, Tubingen, Germany
[2] German Canc Consortium DKTK, partner site Tubingen, Heidelberg, Germany
[3] German Canc Res Ctr, Heidelberg, Germany
[4] Univ Hosp Tubingen, Dept Radiat Oncol, Tubingen, Germany
[5] Univ Tubingen, Sect Expt Radiol, Dept Diagnost & Intervent Radiol, Tubingen, Germany
[6] Univ Tubingen, Dept Diagnost & Intervent Radiol, Tubingen, Germany
[7] Charite Univ Med Berlin, Dept Radiat Oncol, Berlin, Germany
[8] Free Univ Berlin, Berlin Inst Hlth, Humboldt Univ Berlin, Berlin, Germany
[9] Univ Hosp Tubingen, Dept Radiat Oncol, Sect Biomed Phys, Hoppe Seyler Str, D-72076 Tubingen, Germany
关键词
MR guided radiation therapy; Functional imaging; Diffusion-weighted imaging; MR-Linac; Reproducibility; Apparent diffusion coefficient; SQUAMOUS-CELL CARCINOMA; SALIVARY-GLAND FUNCTION; FIELD-STRENGTH; ADAPTIVE RADIOTHERAPY; COEFFICIENT ADC; B-VALUE; BRAIN; VALUES; REPEATABILITY; VARIABILITY;
D O I
10.1016/j.radonc.2023.110046
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background and purpose: Before quantitative imaging biomarkers (QIBs) acquired with magnetic resonance imaging (MRI) can be used for interventional trials in radiotherapy (RT), technical validation of these QIBs is necessary. The aim of this study was to assess the reproducibility of apparent diffusion coefficient (ADC) values, derived from diffusion-weighted (DW) MRI, in head and neck cancer using a 1.5 T MR-Linac (MRL) by comparison to a 3 T diagnostic scanner (DS). Material and methods: DW-MRIs were acquired on MRL and DS for 15 head and neck cancer patients before RT and in week 2 and rigidly registered to the planning computed tomography. Mean ADC values were calculated for submandibular (SG) and parotid (PG) glands as well as target volumes (TV, gross tumor volume and lymph nodes), which were delineated based on computed tomography. Mean absolute ADC differences as well as within-subject coefficient of variation (wCV) and intraclass correlation coefficients (ICCs) were calculated for all volumes of interest. Results: A total of 23 datasets were analyzed. Mean ADC difference (DS-MRL) for SG, PG and TV resulted in 142, 254 and 93 & sdot;10-6 mm2/s. wCVs/ICCs, comparing MRL and DS, were determined as 13.7 %/0.26, 24.4 %/0.23 and 16.1 %/0.73 for SG, PG and TV, respectively. Conclusion: ADC values, measured on the 1.5 T MRL, showed reasonable reproducibility with an ADC underestimation in contrast to the DS. This ADC shift must be validated in further experiments and considered for future translation of QIB candidates from DS to MRL for response adaptive RT.
引用
收藏
页数:8
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