Non-Invasive Diagnostic of NAFLD in Type 2 Diabetes Mellitus and Risk Stratification: Strengths and Limitations

被引：3

作者：

Boeriu, Alina ^{[1
,2
]}

Dobru, Daniela ^{[1
,2
]}

Fofiu, Crina ^{[1
,3
]}

机构：

[1] Univ Med Pharm Sci Technol George Emil Palade Targ, Gastroenterol Dept, Targu Mures 540142, Romania

[2] Mures Cty Clin Hosp, Gastroenterol Dept, Targu Mures 540103, Romania

[3] Bistrita Cty Clin Hosp, Internal Med Dept, Bistrita 420094, Romania

来源：

LIFE-BASEL | 2023年 / 13卷 / 12期

关键词：

diabetes; steatosis; fibrosis; grading; monitoring; biomarkers; imaging; FATTY LIVER-DISEASE; CONTROLLED ATTENUATION PARAMETER; ACCURATELY IDENTIFIES PATIENTS; MAGNETIC-RESONANCE; HEPATIC STEATOSIS; NONALCOHOLIC STEATOHEPATITIS; TRANSIENT ELASTOGRAPHY; STIFFNESS MEASUREMENT; AMINOTRANSFERASE LEVELS; PROSPECTIVE DERIVATION;

D O I：

10.3390/life13122262

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The progressive potential of liver damage in type 2 diabetes mellitus (T2DM) towards advanced fibrosis, end-stage liver disease, and hepatocarcinoma has led to increased concern for quantifying liver injury and individual risk assessment. The combination of blood-based markers and imaging techniques is recommended for the initial evaluation in NAFLD and for regular monitoring to evaluate disease progression. Continued development of ultrasonographic and magnetic resonance imaging methods for accurate quantification of liver steatosis and fibrosis, as well as promising tools for the detection of high-risk NASH, have been noted. In this review, we aim to summarize available evidence regarding the usefulness of non-invasive methods for the assessment of NAFLD in T2DM. We focus on the power and limitations of various methods for diagnosis, risk stratification, and patient monitoring that support their implementation in clinical setting or in research field.

引用

页数：24

共 160 条

[1] Computed tomography findings in liver fibrosis and cirrhosis [J].

Adrian, Huber ;

Lukas, Ebner ;

Matteo, Montani ;

Nasser, Semmo ;

Kingshuk, Roy Choudhury ;

Johannes, Heverhagen ;

Andreas, Christe .

SWISS MEDICAL WEEKLY, 2014, 144

[2] Liver Stiffness on Magnetic Resonance Elastography and the MEFIB Index and Liver-Related Outcomes in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Individual Participants [J].

Ajmera, Veeral ;

Kim, Beom Kyung ;

Yang, Kun ;

Majzoub, Abdul M. ;

Nayfeh, Tarek ;

Tamaki, Nobuharu ;

Izumi, Namiki ;

Nakajima, Atsushi ;

Idilman, Ramazan ;

Gumussoy, Mesut ;

Oz, Digdem Kuru ;

Erden, Ayse ;

Quach, Natalie E. ;

Tu, Xin ;

Zhang, Xinlian ;

Noureddin, Mazen ;

Allen, Alina M. ;

Loomba, Rohit .

GASTROENTEROLOGY, 2022, 163 (04) :1079-+

[3] Imaging biomarkers of NAFLD, NASH, and fibrosis [J].

Ajmera, Veeral ;

Loomba, Rohit .

MOLECULAR METABOLISM, 2020, 50

[4] Clinical Utility of Magnetic Resonance Imaging Biomarkers for Identifying Nonalcoholic Steatohepatitis Patients at High Risk of Progression: A Multicenter Pooled Data and Meta-Analysis [J].

Andersson, Anneli ;

Kelly, Matt ;

Imajo, Kento ;

Nakajima, Atsushi ;

Fallowfield, Jonathan A. ;

Hirschfield, Gideon ;

Pavlides, Michael ;

Sanyal, Arun J. ;

Noureddin, Mazen ;

Banerjee, Rajarshi ;

Dennis, Andrea ;

Harrison, Stephen .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2022, 20 (11) :2451-+

[5] The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD [J].

Angulo, Paul ;

Hui, Jason M. ;

Marchesini, Giulio ;

Bugianesi, Ellisabetta ;

George, Jacob ;

Farrell, Geoffrey C. ;

Enders, Felicity ;

Saksena, Sushma ;

Burt, Alastair D. ;

Bida, John P. ;

Lindor, Keith ;

Sanderson, Schuyler O. ;

Lenzi, Marco ;

Adams, Leon A. ;

Kench, James ;

Therneau, Terry M. ;

Day, Christopher P. .

HEPATOLOGY, 2007, 45 (04) :846-854

[6] Ultrasonographic fatty liver indicator, a novel score which rules out NASH and is correlated with metabolic parameters in NAFLD [J].

Ballestri, Stefano ;

Lonardo, Amedeo ;

Romagnoli, Dante ;

Carulli, Lucia ;

Losi, Luisa ;

Day, Christopher P. ;

Loria, Paola .

LIVER INTERNATIONAL, 2012, 32 (08) :1242-1252

[7] Quantitative magnetic resonance imaging of hepatic steatosis: Validation in ex vivo human livers [J].

Bannas, Peter ;

Kramer, Harald ;

Hernando, Diego ;

Agni, Rashmi ;

Cunningham, Ashley M. ;

Mandal, Rakesh ;

Motosugi, Utaroh ;

Sharma, Samir D. ;

del Rio, Alejandro Munoz ;

Fernandez, Luis ;

Reeder, Scott B. .

HEPATOLOGY, 2015, 62 (05) :1444-1455

[8] The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population [J].

Bedogni, Giorgio ;

Bellentani, Stefano ;

Miglioli, Lucia ;

Masutti, Flora ;

Passalacqua, Marilena ;

Castiglione, Anna ;

Tiribelli, Claudio .

BMC GASTROENTEROLOGY, 2006, 6 (1)

[9] A simple index of lipid overaccumulation is a good marker of liver steatosis [J].

Bedogni, Giorgio ;

Kahn, Henry S. ;

Bellentani, Stefano ;

Tiribelli, Claudio .

BMC GASTROENTEROLOGY, 2010, 10

[10] Serum Proteomics and Biomarker Discovery Across the Spectrum of Nonalcoholic Fatty Liver Disease [J].

Bell, Lauren N. ;

Theodorakis, Janice L. ;

Vuppalanchi, Raj ;

Saxena, Romil ;

Bemis, Kerry G. ;

Wang, Mu ;

Chalasani, Naga .

HEPATOLOGY, 2010, 51 (01) :111-120

← 1 2 3 4 5 6 7 8 9 10 →