Recent Advances in Inherited Cardiac Arrhythmias and Their Genetic Testing

被引：1

作者：

Huse, Shreyash ^{[1
]}

Acharya, Sourya ^{[1
]}

Agrawal, Shashank ^{[1
]}

Harshita, J. ^{[1
]}

Sachdev, Ankita ^{[1
]}

Ghulaxe, Yash ^{[1
]}

Sarda, Prayas ^{[1
]}

Chavada, Jay ^{[1
]}

机构：

[1] Datta Meghe Inst Higher Educ & Res, Jawaharlal Nehru Med Coll, Dept Med, Wardha, India

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 10期

关键词：

inherited arrhythmias; cardiomyopathy; genetic testing; dna sequencing techniques; cardiac sudden death; LONG-QT SYNDROME; EXPERT CONSENSUS STATEMENT; SODIUM-CHANNEL; VENTRICULAR-TACHYCARDIA; BRUGADA-SYNDROME; MUTATIONS; CHANNELOPATHIES; MANAGEMENT; PENETRANCE; PHENOTYPE;

D O I：

10.7759/cureus.47653

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inherited arrhythmias, encompassing conditions such as cardiomyopathies, cardiac ion channel disorders, and coronary heart disease, represent the common causes that elevate the threat of sudden cardiac death among adults. Researchers have pinpointed the genes responsible for these hereditary arrhythmias in the last 30 years. Concurrently, it has become clear that the genetic makeup underlying these conditions is more intricate than previously understood. Evolution in DNA sequencing techniques, particularly next-generation sequencing, has empowered us to learn these intricate hereditary characteristics. Genetic testing is crucial in diagnosing, assessing risk, and determining treatment for individuals with these conditions and their family members. The need for collaborative endeavors to comprehend and address these uncommon yet potentially life-threatening disorders is becoming more evident. This review aims to inform readers of the latest advances in understanding hereditary arrhythmias and provide the groundwork for collaborative genetic testing initiatives to characterize these disorders in the general population.

引用

页数：8

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