Development and Challenges of Synthetic Retinoid Formulations in Cancer

被引：10
作者：
Assi, Sara [1 ]
El Hajj, Hiba [2 ]
Hayar, Berthe [3 ]
Pisano, Claudio [4 ]
Saad, Walid [5 ]
Darwiche, Nadine [3 ]
机构：
[1] Amer Univ Beirut, Maroun Semaan Fac Engn & Architecture, Dept Biomed Engn, Beirut, Lebanon
[2] Amer Univ Beirut, Fac Med, Dept Expt Pathol Immunol & Microbiol, Beirut, Lebanon
[3] Amer Univ Beirut, Fac Med, Dept Biochem & Mol Genet, POB 11-0236, Beirut 11072020, Lebanon
[4] Inst Mol Biol & Genet, Biogem, Via Camporeale, I-83031 Ariano Irpino, AV, Italy
[5] Amer Univ Beirut, Maroun Semaan Fac Engn & Architecture, Dept Chem Engn, POB 11-0236, Beirut 11072020, Lebanon
来源：
CURRENT DRUG DELIVERY | 2023年 / 20卷 / 09期
关键词：
Synthetic retinoid; delivery system; formulation; development; drug; cancer; MYELOID-LEUKEMIA CELLS; ACUTE PROMYELOCYTIC LEUKEMIA; RECEPTOR AGONIST BEXAROTENE; X-RECEPTOR; ANTITUMOR-ACTIVITY; PLGA MICROSPHERES; SOLID DISPERSIONS; RESISTANT NEUROBLASTOMA; THERAPEUTIC-EFFICACY; SURFACE MODIFICATION;
D O I：
10.2174/1567201819666220810094708
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Retinoids represent a class of chemical compounds derived from or structurally and functionally related to vitamin A. Retinoids play crucial roles in regulating a range of crucial biological processes spanning embryonic development to adult life. These include regulation of cell proliferation, differentiation, and cell death. Due to their promising characteristics, retinoids emerged as potent anti-cancer agents, and their effects were validated in vitro and in vivo preclinical models of several solid and hematological malignancies. However, their clinical translation remained limited due to poor water solubility, photosensitivity, short half-life, and toxicity. The development of retinoid delivery formulations was extensively studied to overcome these limitations. This review will summarize some preclinical and commercial synthetic retinoids in cancer and discuss their different delivery systems.
引用
收藏
页码：1314 / 1326
页数：13
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