Associations between prenatal exposure to polycyclic aromatic hydrocarbons and thyroid hormones in umbilical cord blood

被引：3
|
作者：
Yao, Xiyuan [1 ]
Wang, Yidong [1 ]
Ma, Yifei [1 ]
Fu, Mengmeng [1 ]
Wang, Huimin [1 ]
Tang, Deliang [2 ]
Nie, Jisheng [1 ]
机构：
[1] Shanxi Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Xinjiannan Rd 56, Taiyuan 030001, Peoples R China
[2] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, 722 W 168Th St, New York, NY 10032 USA
来源：
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2023年 / 30卷 / 31期
基金：
中国国家自然科学基金;
关键词：
Prenatal; Polycyclic aromatic hydrocarbons; Neonatal; Thyroid hormones; Umbilical cord blood; The dose-response association; PERFLUOROALKYL SUBSTANCES; STIMULATING HORMONE; DNA METHYLATION; ENDOCRINE; PREGNANCY; METABOLITES; ADDUCTS; HEALTH; IMPACT; PYRENE;
D O I：
10.1007/s11356-023-27379-2
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
We explored the association between maternal urinary polycyclic aromatic hydrocarbon (PAH) metabolites and thyroid hormones in umbilical cord blood in 120 pairs of pregnant women and newborns. Maternal urinary PAH metabolites were measured using high-performance liquid chromatography with tandem mass spectrometry. Thyroid hormones were measured using a flow fluorescence assay. The dose-response relationship between PAH metabolites and thyroid hormones was analyzed using the generalized linear model and restricted cubic spline model. Results showed that Sigma OH PAHs in maternal urine had a negative effect on triiodothyronine (T3). Associations between maternal urinary PAH metabolites and thyroid hormones in umbilical cord blood plasma were observed. Prenatal exposure to PAHs could affect neonatal thyroid hormones, thereby disrupting neonatal thyroid function.
引用
收藏
页码：77096 / 77106
页数：11
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