Cortical microstructural gradients capture memory network reorganization in temporal lobe epilepsy

被引:21
作者
Royer, Jessica [1 ,2 ,10 ]
Lariviere, Sara [1 ]
Rodriguez-Cruces, Raul [1 ]
Cabalo, Donna Gift [1 ]
Tavakol, Shahin [1 ]
Auer, Hans [1 ]
Ngo, Alexander [1 ]
Park, Bo-yong [1 ,3 ,4 ]
Paquola, Casey [5 ]
Smallwood, Jonathan [6 ]
Jefferies, Elizabeth [7 ]
Caciagli, Lorenzo [8 ]
Bernasconi, Andrea
Bernasconi, Neda [9 ]
Frauscher, Birgit [2 ]
Bernhardt, Boris C. [1 ,10 ]
机构
[1] McGill Univ, Montreal Neurol Inst & Hosp, Multimodal Imaging & Connectome Anal Lab, Montreal, PQ H3A 2B4, Canada
[2] McGill Univ, Montreal Neurol Inst & Hosp, Analyt Neurophysiol Lab, Montreal, PQ H3A 2B4, Canada
[3] Inha Univ, Dept Data Sci, Incheon 22212, South Korea
[4] Inst Basic Sci, Ctr Neurosci Imaging Res, Suwon 34126, South Korea
[5] Forschungszentrum Julich, Multiscale Neuroanat Lab, INM 1, D-52425 Julich, Germany
[6] Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada
[7] Univ York, Dept Psychol, York YO10 5DD, England
[8] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
[9] McGill Univ, Montreal Neurol Inst & Hosp, Neuroimaging Epilepsy Lab, Montreal, PQ H3A 2B4, Canada
[10] 3801 Rue Univ, Montreal, PQ H3A 2B4, Canada
基金
新加坡国家研究基金会; 加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
epilepsy; neuroimaging; memory; microstructure; structure-function; GRANULE CELL DISPERSION; SURFACE-BASED ANALYSIS; DEFAULT-MODE NETWORK; QUALITY-OF-LIFE; HIPPOCAMPAL SCLEROSIS; VERBAL MEMORY; HUMAN BRAIN; EPISODIC MEMORY; PROTEIN GAP-43; MRI;
D O I
10.1093/brain/awad125
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Temporal lobe epilepsy (TLE), one of the most common pharmaco-resistant epilepsies, is associated with pathology of paralimbic brain regions, particularly in the mesiotemporal lobe. Cognitive dysfunction in TLE is frequent, and particularly affects episodic memory. Crucially, these difficulties challenge the quality of life of patients, sometimes more than seizures, underscoring the need to assess neural processes of cognitive dysfunction in TLE to improve patient management. Our work harnessed a novel conceptual and analytical approach to assess spatial gradients of microstructural differentiation between cortical areas based on high-resolution MRI analysis. Gradients track region-to-region variations in intracortical lamination and myeloarchitecture, serving as a system-level measure of structural and functional reorganization. Comparing cortex-wide microstructural gradients between 21 patients and 35 healthy controls, we observed a reorganization of this gradient in TLE driven by reduced microstructural differentiation between paralimbic cortices and the remaining cortex with marked abnormalities in ipsilateral temporopolar and dorsolateral prefrontal regions. Findings were replicated in an independent cohort. Using an independent post-mortem dataset, we observed that in vivo findings reflected topographical variations in cortical cytoarchitecture. We indeed found that macroscale changes in microstructural differentiation in TLE reflected increased similarity of paralimbic and primary sensory/motor regions. Disease-related transcriptomics could furthermore show specificity of our findings to TLE over other common epilepsy syndromes. Finally, microstructural dedifferentiation was associated with cognitive network reorganization seen during an episodic memory functional MRI paradigm and correlated with interindividual differences in task accuracy. Collectively, our findings showing a pattern of reduced microarchitectural differentiation between paralimbic regions and the remaining cortex provide a structurally-grounded explanation for large-scale functional network reorganization and cognitive dysfunction characteristic of TLE.
引用
收藏
页码:3923 / 3937
页数:15
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