Low glomerular number at birth can lead to the development of chronic kidney disease

被引:2
作者
Fukunaga, Shohei [1 ]
Fujita, Yuki [2 ]
机构
[1] Shimane Univ Hosp, Div Nephrol, Izumo, Shimane, Japan
[2] Shimane Univ, Dept Dev Biol, Fac Med, Izumo, Shimane, Japan
来源
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
关键词
glomerular number; chronic kidney disease; maternal malnutrition; low birth weight; nephron development; CHRONIC-RENAL-FAILURE; HIGH-FAT DIET; NEPHRON NUMBER; RETINOIC ACID; PROTEIN RESTRICTION; PRENATAL EXPOSURE; BLOOD-PRESSURE; WEIGHT; SIZE; EXPRESSION;
D O I
10.3389/fendo.2023.1120801
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chronic kidney disease (CKD) prevalence is increasing worldwide, and reducing the number of patients with CKD is of utmost importance. The environment during the fetal, perinatal, and early childhood stages may influence CKD development (developmental origins of health and disease). Under conditions of maternal malnutrition, the glomerular number of infants reduces, and the risk of developing CKD may increase. Nephron progenitor cells and ureteric buds interact with each other to form glomeruli at the tip of the ureteric bud. Thus, the number of glomeruli is determined by the number of ureteric bud branches, which are reportedly decreased due to maternal malnutrition, in turn reducing the glomerular number. Four possible mechanisms can explain the low glomerular number resulting from maternal malnutrition: 1) suppression of c-Ret expression, 2) suppression of nephron formation by renin-angiotensin-aldosterone system inhibition, 3) exposure to excess glucocorticoids, and 4) promotion of apoptosis. Additionally, nephron formation does not continue after birth in humans. Therefore, a low glomerular number at birth is a lifelong burden on the glomeruli and increases the risk of developing CKD. Therefore, it is important to maintain the glomerular number at birth. Accurate glomerular counts are essential for conducting studies on the glomerular number. The dissector/fractionator method is the gold standard; however, it can only be performed at some institutions. Recently, methods have been developed to measure the glomerular number by combining computed tomography and pathological examination and measure the glomerular count using magnetic resonance imaging. Models of decreased and increased glomerular numbers have been developed. Moreover, research regarding the causes of decreased glomerular number and its relationship with development of lifestyle-related diseases and renal dysfunction has significantly progressed, furthering our understanding of the importance of glomerular number.
引用
收藏
页数:8
相关论文
共 66 条
  • [11] GLOMERULI AND BLOOD-PRESSURE - LESS OF ONE, MORE THE OTHER
    BRENNER, BM
    GARCIA, DL
    ANDERSON, S
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 1988, 1 (04) : 335 - 347
  • [12] Adult Renal Size is Not a Suitable Marker for Nephron Numbers: An Individual Patient Data Meta-Analysis
    Bueters, Ruud R. G.
    van de Kar, Nicole C. A. J.
    Schreuder, Michiel F.
    [J]. KIDNEY & BLOOD PRESSURE RESEARCH, 2013, 37 (06) : 540 - 546
  • [13] PHENOTYPIC MANIFESTATIONS OF BRANCHIOOTORENAL SYNDROME
    CHEN, A
    FRANCIS, M
    NI, L
    CREMERS, CWRJ
    KIMBERLING, WJ
    SATO, Y
    PHELPS, PD
    BELLMAN, SC
    WAGNER, MJ
    PEMBREY, M
    SMITH, RJH
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1995, 58 (04): : 365 - 370
  • [14] Perturbations of genes essential for Mullerian duct and Wolffian duct development in Mayer-Rokitansky-Kuster-Hauser syndrome
    Chen, Na
    Zhao, Sen
    Jolly, Angad
    Wang, Lianlei
    Pan, Hongxin
    Yuan, Jian
    Chen, Shaoke
    Koch, Andre
    Ma, Congcong
    Tian, Weijie
    Jia, Ziqi
    Kang, Jia
    Zhao, Lina
    Qin, Chenglu
    Fan, Xin
    Rall, Katharina
    Coban-Akdemir, Zeynep
    Chen, Zefu
    Jhangiani, Shalini
    Liang, Ze
    Niu, Yuchen
    Li, Xiaoxin
    Yan, Zihui
    Wu, Yong
    Dong, Shuangshuang
    Song, Chengcheng
    Qiu, Guixing
    Zhang, Shuyang
    Liu, Pengfei
    Posey, Jennifer E.
    Zhang, Feng
    Luo, Guangnan
    Wu, Zhihong
    Su, Jianzhong
    Zhang, Jianguo
    Chen, Eugenia Y.
    Rouskas, Konstantinos
    Glentis, Stavros
    Bacopoulou, Flora
    Deligeoroglou, Efthymios
    Chrousos, George
    Lyonnet, Stanislas
    Polak, Michel
    Rosenberg, Carla
    Dingeldein, Irene
    Bonilla, Ximena
    Borel, Christelle
    Gibbs, Richard A.
    Dietrich, Jennifer E.
    Dimas, Antigone S.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2021, 108 (02) : 337 - 345
  • [15] Role of renal NO production in the regulation of medullary blood flow
    Cowley, AW
    Mori, T
    Mattson, D
    Zou, AP
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2003, 284 (06) : R1355 - R1369
  • [16] Cullen-McEwen Luise A, 2012, Methods Mol Biol, V886, P333, DOI 10.1007/978-1-61779-851-1_30
  • [17] A design-based method for estimating glomerular number in the developing kidney
    Cullen-McEwen, Luise A.
    Armitage, James A.
    Nyengaard, Jens R.
    Moritz, Karen M.
    Bertram, John F.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2011, 300 (06) : F1448 - F1453
  • [18] The association of low birthweight and chronic renal failure among Medicaid young adults with diabetes and/or hypertension
    Fan, ZJ
    Lackland, DT
    Lipsitz, SR
    Nicholas, JS
    [J]. PUBLIC HEALTH REPORTS, 2006, 121 (03) : 239 - 244
  • [19] Administration of retinoic acid to pregnant mice increases the number of fetal mouse glomeruli
    Fukunaga, Shohei
    Ogawa, Noriko
    Matsumoto, Akihiro
    Ito, Takafumi
    Tanabe, Kazuaki
    Otani, Hiroki
    [J]. BIOCHEMISTRY AND BIOPHYSICS REPORTS, 2022, 30
  • [20] Optimal route of diphtheria toxin administration to eliminate native nephron progenitor cells in vivo for kidney regeneration
    Fukunaga, Shohei
    Yamanaka, Shuichiro
    Fujimoto, Toshinari
    Tajiri, Susumu
    Uchiyama, Taketo
    Matsumoto, Kei
    Ito, Takafumi
    Tanabe, Kazuaki
    Yokoo, Takashi
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 496 (04) : 1176 - 1182