Association of Insulin-like Growth Factor-1 and Neurofilament Light Chain in Patients with Progressive Supranuclear Palsy

被引:2
作者
Dey, Saikat [1 ]
Yelamanchi, Ramachadra [2 ]
Mullapudi, Thrinath [1 ]
Holla, Vikram V. [2 ]
Kamble, Nitish [2 ]
Mahale, Rohan R. [2 ]
Sathyaprabha, Talakad N. [3 ]
Pal, Pramod K. [2 ]
Debnath, Monojit [1 ]
Yadav, Ravi [2 ,4 ]
机构
[1] Natl Inst Mental Hlth & Neurosci, Dept Human Genet, Bangalore, Karnataka, India
[2] Natl Inst Mental Hlth & Neurosci, Dept Neurol, Bangalore, Karnataka, India
[3] Natl Inst Mental Hlth & Neurosci, Dept Neurophysiol, Bangalore, Karnataka, India
[4] Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Neurol, Hosur Rd, Bengaluru 560029, Karnataka, India
关键词
Biomarker; insulin-like growth factor-1; neurofilament light chain; progressive supranuclear palsy; PSP variants; DIAGNOSIS; BIOMARKER; SURVIVAL; RISK; NFL;
D O I
10.4103/aian.aian_507_23
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Progressive supranuclear palsy (PSP) is the most common primary tauopathy. The definite diagnosis of PSP is established by histopathologic changes in the brain. There are no reliable blood-based biomarkers to aid the diagnosis of this fatal disease at an early stage. Also, the precise etiopathology of PSP and its variants is inadequately understood. Objective: Blood-based molecules such as neurofilament light chain (NfL) and insulin-like growth factor-1 (IGF-1) are shown as important markers of neurodegenerative and aging processes, respectively. These two biomarkers have not been analyzed simultaneously in PSP patients. Methods: To address this knowledge gap, 40 PSP patients and equal number of healthy individuals were recruited and serum levels of NfL and IGF-1 were assayed in all the study participants by enzyme-linked immunosorbent assay (ELISA). Motor and nonmotor symptoms were evaluated in PSP patients using various scales/questionnaires. Cardiac autonomic function tests were performed in a subset of patients (n = 27). Results: A significantly high serum level of NfL (P < 0.01) and a reduced level of IGF-1 (P = 0.02) were observed in PSP patients compared to healthy controls. Besides, a negative correlation (r = -0.54, P < 0.01) between NfL and IGF-1 levels was observed in PSP patients. Conclusion: The finding of this study reinforces the important role of blood NfL level as a potential biomarker of PSP. Further, the current study provides novel insights into the reciprocal correlation between NfL and IGF-1 in PSP patients. Combined analysis of blood levels of these two functionally relevant markers might be useful in the prediction and diagnosis of PSP.
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页码:40 / 45
页数:7
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