Diagnostic, prognostic, and therapeutic potential of exosomal microRNAs in renal cancer

被引：5

作者：

Yu, Xiaodong ^{[1
]}

Du, Zhongbo ^{[1
]}

Zhu, Pingyu ^{[1
]}

Liao, Bo ^{[1
]}

机构：

[1] North Sichuan Med Coll, Dept Urol, Affiliated Hosp, Nanchong 637000, Peoples R China

来源：

PHARMACOLOGICAL REPORTS | 2024年 / 76卷 / 02期

关键词：

Exosome; MicroRNA; Renal cell carcinoma; Diagnosis; Prognosis; Therapy; CELL CARCINOMA; COLORECTAL-CANCER; STEM-CELLS; HEPATOCELLULAR-CARCINOMA; NONINVASIVE BIOMARKERS; MESENCHYMAL TRANSITION; CIRCULATING EXOSOMES; VASCULOGENIC MIMICRY; ENDOTHELIAL-CELLS; TUMOR PROGRESSION;

D O I：

10.1007/s43440-024-00568-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Renal cell carcinoma (RCC) arises from the tubular epithelial cells of the nephron. It has the highest mortality rate among urological cancers. There are no effective therapeutic approaches and no non-invasive biomarkers for diagnosis and follow-up. Thus, suitable novel biomarkers and therapeutic targets are essential for improving RCC diagnosis/prognosis and treatment. Circulating exosomes such as exosomal microRNAs (Exo-miRs) provide non-invasive prognostic/diagnostic biomarkers and valuable therapeutic targets, as they can be easily isolated and quantified and show high sensitivity and specificity. Exosomes secreted by an RCC can exhibit alterations in the miRs' profile that may reflect the cellular origin and (patho)physiological state, as a ''signature'' or ''fingerprint'' of the donor cell. It has been shown that the transportation of renal-specific miRs in exosomes can be rapidly detected and measured, holding great potential as biomarkers in RCC. The present review highlights the studies reporting tumor microenvironment-derived Exo-miRs with therapeutic potential as well as circulating Exo-miRs as potential diagnostic/prognostic biomarkers in patients with RCC.

引用

页码：273 / 286

页数：14

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