Synthesis, Biological Evaluation, and Molecular Docking Study of New Pyrazoline-Based Compounds

The current study represents the synthesis and characterization of new pyrazoline, pyrazoline-thiazolinone, and pyrazoline-thiazole-based derivatives, using 1-(4-aminophenyl)-3-substituted phenylprop-2-en-1-ones as the key intermediate precursors. In order to decrease the reaction times and boost the yields of the target compounds, microwave irradiation at 80 degrees C was utilized to synthesize the pyrazoline and thiazolinone derivatives. All the new analogues were subjected to antimicrobial evaluation against different gram-positive, gram-negative bacteria and the pathogenic yeast Candida albicans. In addition, the docking simulation study of the thiazolinone and the thiazole derivatives against VEGFR-2 kinase was carried out in comparison with the ligand sorafenib. The results confirmed that the pyrazoline-thiazole compounds represented good stability and fixation within the active site of VEGFR-2 and could be considered basic scaffolds for the discovery of new promising anticancer compounds.