The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease

被引：5
|
作者：
Cai, Meichao [1 ]
Zhao, Dongsheng [1 ]
Han, Xiao [1 ]
Han, Shuang [2 ]
Zhang, Wenxin [1 ]
Zang, Zhennan [1 ]
Gai, Chenchen [1 ]
Rong, Rong [1 ]
Gao, Tian [1 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Sch Pharm, Jinan, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Int Peace Matern & Child Hlth Hosp, Shanghai, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
perivascular adipose tissue (PVAT); adipocytokines (adipokines); white adipose tissue (WAT); brown adipose tissue (BAT); cardiovascular disease; NITRIC-OXIDE SYNTHASE; INFLAMMATORY RESPONSE; ADIPONECTIN RECEPTORS; MESSENGER-RNA; EXPRESSION; OMENTIN; GROWTH; CELLS; LEPTIN; FAT;
D O I：
10.3389/fimmu.2023.1271051
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Perivascular adipose tissue and the vessel wall are connected through intricate bidirectional paracrine and vascular secretory signaling pathways. The secretion of inflammatory factors and oxidative products by the vessel wall in the diseased segment has the ability to influence the phenotype of perivascular adipocytes. Additionally, the secretion of adipokines by perivascular adipose tissue exacerbates the inflammatory response in the diseased vessel wall. Therefore, quantitative and qualitative studies of perivascular adipose tissue are of great value in the context of vascular inflammation and may provide a reference for the assessment of cardiovascular ischemic disease.
引用
收藏
页数：8
相关论文
共 50 条
  • [1] The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease
    Ouwens, D. Margriet
    Sell, Henrike
    Greulich, Sabrina
    Eckel, Juergen
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2010, 14 (09) : 2223 - 2234
  • [2] Perivascular adipose tissue in the pathogenesis of cardiovascular disease
    Lee, Hae-Young
    Despres, Jean-Pierre
    Koh, Kwang Kon
    ATHEROSCLEROSIS, 2013, 230 (02) : 177 - 184
  • [3] Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease
    Meijer, Rick I.
    Serne, Erik H.
    Smulders, Yvo M.
    van Hinsbergh, Victor W. M.
    Yudkin, John S.
    Eringa, Etto C.
    CURRENT DIABETES REPORTS, 2011, 11 (03) : 211 - 217
  • [4] Role of Perivascular Adipose Tissue in Health and Disease
    Fernandez-Alfonso, Maria S.
    Somoza, Beatriz
    Tsvetkov, Dmitry
    Kuczmanski, Artur
    Dashwood, Mick
    Gil-Ortega, Marta
    COMPREHENSIVE PHYSIOLOGY, 2018, 8 (01) : 23 - 59
  • [5] Potential role of perivascular adipose tissue in modulating atherosclerosis
    Ahmadieh, Samah
    Kim, Ha Won
    Weintraub, Neal L.
    CLINICAL SCIENCE, 2020, 134 (01) : 3 - 13
  • [6] Perivascular Adipose Tissue as an Endocrine Organ: The Role of Statins
    Sanna, Fabio
    Margaritis, Marios
    Antoniades, Charalambos
    CURRENT PHARMACEUTICAL DESIGN, 2017, 23 (46) : 7055 - 7060
  • [7] The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease
    Chen, Hong-Jin
    Meng, Ting
    Gao, Ping-Jin
    Ruan, Cheng-Chao
    FRONTIERS IN ENDOCRINOLOGY, 2021, 12
  • [8] Perivascular adipose tissue in cardiovascular diseases-an update
    Grigoras, Adriana
    Amalinei, Cornelia
    Balan, Raluca Anca
    Giusca, Simona Eliza
    Caruntu, Irina Draga
    ANATOLIAN JOURNAL OF CARDIOLOGY, 2019, 22 (05) : 219 - 231
  • [9] Epicardial Adipose Tissue in Cardiovascular Disease
    Berg, Gabriela
    Miksztowicz, Veronica
    Morales, Celina
    Barchuk, Magali
    BIOACTIVE LIPIDS IN HEALTH AND DISEASE, 2019, 1127 : 131 - 143
  • [10] The role of adipose tissue in cardiovascular health and disease
    Oikonomou, Evangelos K.
    Antoniades, Charalambos
    NATURE REVIEWS CARDIOLOGY, 2019, 16 (02) : 83 - 99
12345