Ecofriendly analytical quality by design-based method for determining Metronidazole, Lidocaine and Miconazole using RP-HPLC in semisolid dosage form

被引:10
作者
Sukumar, Viswanathan [1 ]
Chanduluru, Hemanth Kumar [2 ,4 ]
Chinnusamy, Saravanan [1 ,3 ]
机构
[1] Sona Coll Technol, Ctr Adv Res Organ Mat Sona AROMA, Dept Chem, Salem, India
[2] SRM Coll Pharm, SRMIST, Dept Pharmaceut Anal, Chennai, Tamil Nadu, India
[3] Sona Coll Technol, Ctr Adv Res Organ Mat Sona AROMA, Dept Chem, Salem 636005, Tamil Nadu, India
[4] SRMIST, SRM Coll Pharm, Chennai 603203, Tamil Nadu, India
关键词
Analytical quality by design; Green analytical chemistry; HPLC; Lidocaine; Metronidazole; Miconazole; GREEN ANALYTICAL-CHEMISTRY; NITRATE; QUANTIFICATION; HYDROCHLORIDE; COMBINATION; VALIDATION;
D O I
10.1080/16583655.2023.2252593
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The article deals with the development of an analytical method based on AQbD and GAC for the simultaneous determination of Metronidazole (MET), Lidocaine (LID) and Miconazole (MIC) in oval dosage form using RP-HPLC. The separation was achieved on the stationary phase Zorbax C18 150 mm x 4.6 mm (i.d); 5 & mu;m, using a gradient mobile phase containing Ethanol and Phosphate buffers. The linearity has been obtained for MET's 240-390 & mu;g/mL, 32-52 & mu;g/mL for LID and 64-104 & mu;g/mL for MIC, with their LOD and LOQ as 31.25, 94.705 & mu;g/mL (MIC) 1.463, 4.433 & mu;g/mL (LID) and 7.981, 24.187 & mu;g/mL for MIC, respectively. Finally, the method assessed for greenness using the three tools showed that the developed method was eco-friendly. The developed method is simple and reliable with a design space that helps for further improvement and is eco-friendly, making this method unique for adoption in regular quality control analysis.
引用
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页数:10
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