The alternative complement pathway triggers neuroinflammation, glial activation, and retinal ganglion cell death in a microbead induced mouse model of glaucoma

被引:0
|
作者
Hoppe, Cindy [1 ,2 ]
Refaian, Nasrin [1 ]
Krasniqi, Drenushe [1 ]
Nwogu, Amarachi [1 ]
Guo, Yinjie [1 ]
Shrestha, Maleeka [1 ]
Connor, Kip M. [3 ]
Gregory-Ksander, Meredith S. [1 ]
机构
[1] Harvard Med Sch, Dept Ophthalmol, Schepens Eye Res Inst, Massachusetts Eye & Ear, Boston, MA USA
[2] Friedrich Alexander Univ Erlangen Nurnberg, Dept Biol Anim Physiol Neurobiol, Erlangen, Germany
[3] Harvard Med Sch, Dept Ophthalmol, Massachusetts Eye & Ear, Boston, MA USA
关键词
D O I
暂无
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [41] Angiotensin II related glial cell activation and necroptosis of retinal ganglion cells after systemic hypotension in glaucoma
    Jeon, Soo Ji
    Huh, Jungbin
    Jeong, Eojin
    Park, Chan Kee
    Park, Hae Young Lopilly
    CELL DEATH & DISEASE, 2022, 13 (04)
  • [42] Angiotensin II related glial cell activation and necroptosis of retinal ganglion cells after systemic hypotension in glaucoma
    Soo Ji Jeon
    Jungbin Huh
    Eojin Jeong
    Chan Kee Park
    Hae Young Lopilly Park
    Cell Death & Disease, 13
  • [43] Enhanced retinal ganglion cell loss is accompanied by microglia activation in a multifactorial glaucoma model
    Reinehr, Sabrina
    Girbig, Renee M.
    Theile, Janine
    Fuchshofer, Rudolf
    Dick, H. Bukhard
    Joachim, Stephanie C.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2022, 63 (07)
  • [44] All-trans-Retinal Sensitizes Human RPE Cells to Alternative Complement Pathway-Induced Cell Death
    Berchuck, Jacob E.
    Yang, Ping
    Toimil, Brett A.
    Ma, Zhe
    Baciu, Peter
    Jaffe, Glenn J.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (04) : 2669 - 2677
  • [45] Inhibition of cGAS-STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia/reperfusion injury
    Wu, Xingdi
    Yu, Naiji
    Ye, Zifan
    Gu, Yuxiang
    Zhang, Chengshou
    Chen, Min
    Wang, Kaijun
    CELL DEATH & DISEASE, 2023, 14 (09)
  • [46] Angiotensin II-Related Activation of Scleral Fibroblasts and Their Role on Retinal Ganglion Cell Death in Glaucoma
    Oh, Si-Eun
    Kim, Jie-Hyun
    Shin, Hee-Jong
    Kim, Seong-Ah
    Park, Chan-Kee
    Park, Hae-Young Lopilly
    PHARMACEUTICALS, 2023, 16 (04)
  • [47] Manipulation of retinal glutamate levels by overexpression of GLAST reduces retinal ganglion cell death in an experimental model of glaucoma
    Kimura, Atsuko
    Namekata, Kazuhiko
    Guo, Xiaoli
    Azuchi, Yuriko
    Harada, Chikako
    Harada, Takayuki
    BRAIN PATHOLOGY, 2019, 29 : 89 - 89
  • [48] Cullin-5 is associated with retinal ganglion cell (RGC) death in glaucoma model mice
    Okumichi, H
    Kanamoto, T
    Tanimoto, S
    Suzuki, M
    Tamura, H
    Mishima, HK
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46
  • [49] Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy
    Luo, Wentian
    Olaru, Florina
    Miner, Jeffrey H.
    Beck, Laurence H., Jr.
    van der Vlag, Johan
    Thurman, Joshua M.
    Borza, Dorin-Bogdan
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [50] A New Mouse Model of Inducible, Chronic Retinal Ganglion Cell Dysfunction Not Associated with Cell Death
    Yang, Xu
    Chou, Tsung-Han
    Ruggeri, Marco
    Porciatti, Vittorio
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (03) : 1898 - 1904