Traumatic brain injury and the pathways to cerebral tau accumulation

被引:5
|
作者
Flavin, William P. [1 ,2 ]
Hosseini, Helia [3 ]
Ruberti, Jeffrey W. [4 ]
Kavehpour, H. Pirouz [3 ,5 ]
Giza, Christopher C. [2 ,3 ,6 ]
Prins, Mayumi L. [2 ,3 ,6 ]
机构
[1] UCLA, David Geffen Sch Med, Dept Neurol, Los Angeles, CA USA
[2] UCLA, David Geffen Sch Med, Dept Pediat & Neurosurg, Steve Tisch BrainSPORT Program, Los Angeles, CA 90095 USA
[3] UCLA, Dept Bioengn, Los Angeles, CA 90095 USA
[4] Northeastern Univ, Dept Bioengn, Boston, MA USA
[5] UCLA, Dept Mech & Aerosp Engn, Los Angeles, CA USA
[6] UCLA, Brain Injury Res Ctr, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA
来源
FRONTIERS IN NEUROLOGY | 2023年 / 14卷
关键词
tau; traumatic brain injury; neurodegeneration; brain pathology; repetitive head injury; ALZHEIMERS-DISEASE; PATHOLOGICAL TAU; ALPHA-SYNUCLEIN; POSTTRANSLATIONAL MODIFICATIONS; HYPERPHOSPHORYLATED TAU; CEREBROSPINAL-FLUID; PATHOGENIC TAU; CLEAVED-TAU; PROTEIN-TAU; BETA;
D O I
10.3389/fneur.2023.1239653
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Tau is a protein that has received national mainstream recognition for its potential negative impact to the brain. This review succinctly provides information on the structure of tau and its normal physiological functions, including in hibernation and changes throughout the estrus cycle. There are many pathways involved in phosphorylating tau including diabetes, stroke, Alzheimer's disease (AD), brain injury, aging, and drug use. The common mechanisms for these processes are put into context with changes observed in mild and repetitive mild traumatic brain injury (TBI). The phosphorylation of tau is a part of the progression to pathology, but the ability for tau to aggregate and propagate is also addressed. Summarizing both the functional and dysfunctional roles of tau can help advance our understanding of this complex protein, improve our care for individuals with a history of TBI, and lead to development of therapeutic interventions to prevent or reverse tau-mediated neurodegeneration.
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页数:17
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