Gold nanocluster-based fluorescent sensors for in vitro and in vivo ratiometric imaging of biomolecules

被引:12
作者
Santhoshkumar, S. [1 ]
Madhu, Manivannan [1 ]
Tseng, Wei-Bin [1 ,2 ]
Tseng, Wei-Lung [1 ,3 ]
机构
[1] Natl Sun Yat sen Univ, Dept Chem, 70 Lien hai Rd, Kaohsiung 80424, Taiwan
[2] Da Yeh Univ, Dept Environm Engn, 168 Univ Rd, Changhua 515006, Taiwan
[3] Kaohsiung Med Univ, Sch Pharm, 100 Shiquan 1st Rd, Kaohsiung 80708, Taiwan
关键词
PROTEIN-DIRECTED SYNTHESIS; CANCER-CELLS; NANOPARTICLES; CLUSTERS; PROBE; PH; BIODISTRIBUTION; HOMOCYSTEINE; GLUTATHIONE; NANOSHEETS;
D O I
10.1039/d3cp02714g
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Gold nanoclusters (AuNCs) are promising nanomaterials for ratiometric fluorescent probes due to their tunable fluorescence wavelengths dependent on size and structure, as well as their biocompatibility and resistance to photobleaching. By incorporating an additional fluorescence spectral peak, dual-emission AuNC-based fluorescent probes have been developed to enhance the signal output reproducibility. These probes can be fabricated by integrating various luminescent nanomaterials with AuNCs. This review focuses on the preparation methods and applications of ratiometric fluorescent probes derived from AuNCs and other fluorescent nanomaterials or fluorescent dyes for both in vitro and in vivo bioimaging of target analytes. Additionally, the review delves into the sensing mechanisms of AuNC-based ratiometric probes, their synthetic strategies, and the challenges encountered when using AuNCs for ratiometric bioimaging. Moreover, we explore the application of protein-stabilized AuNCs and thiolate-capped AuNC-based ratiometric fluorescent probes for biosensing and bioimaging. Two primary methods for assembling AuNCs and fluorophores into ratiometric fluorescent probes are discussed: triggered assembly and self-assembly. Finally, we address the challenges and issues associated with ratiometric bioimaging using AuNCs and propose future directions for further advancing AuNCs as ratiometric imaging agents.
引用
收藏
页码:21787 / 21801
页数:15
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