Towards Ruthenium(II)-Rhenium(I) Binuclear Complexes as Photosensitizers for Photodynamic Therapy

被引：4
作者：
Wang, Youchao [1 ]
Felder, Patrick S. S. [1 ]
Mesdom, Pierre [1 ]
Blacque, Olivier [2 ]
Mindt, Thomas L. L. [3 ,4 ,5 ]
Cariou, Kevin [1 ]
Gasser, Gilles [1 ]
机构：
[1] PSL Univ, Inst Chem Life & Hlth Sci, Lab Inorgan Chem Biol, ChimieParisTech,CNRS, F-75005 Paris, France
[2] Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland
[3] Univ Vienna, Inst Inorgan Chem, Fac Chem, Wahringerstr 42, A-1090 Vienna, Austria
[4] Univ Vienna, Joint Appl Med Radiochem Facil, Wahringerstr 42, A-1090 Vienna, Austria
[5] Med Univ Vienna, Wahringer Gurtel 18-20, A-1090 Vienna, Austria
来源：
CHEMBIOCHEM | 2023年 / 24卷 / 19期
基金：
奥地利科学基金会;
关键词：
bioinorganic chemistry; metals in medicine; photodynamic therapy; Rhenium(I) complex; Ruthenium(II) complex; RU(II) POLYPYRIDYL COMPLEXES; INTRAMOLECULAR ENERGY-TRANSFER; RHENIUM; CANCER; PHOTOPHYSICS; RUTHENIUM;
D O I：
10.1002/cbic.202300467
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The search for new metal-based photosensitizers (PSs) for anticancer photodynamic therapy (PDT) is a fast-developing field of research. Knowing that polymetallic complexes bear a high potential as PDT PSs, in this study, we aimed at combining the known photophysical properties of a rhenium(I) tricarbonyl complex and a ruthenium(II) polypyridyl complex to prepare a ruthenium-rhenium binuclear complex that could act as a PS for anticancer PDT. Herein, we present the synthesis and characterization of such a system and discuss its stability in aqueous solution. In addition, one of our complexes prepared, which localized in mitochondria, was found to have some degree of selectivity towards two types of cancerous cells: human lung carcinoma A549 and human colon colorectal adenocarcinoma HT29, with interesting photo-index (PI) values of 135.1 and 256.4, respectively, compared to noncancerous retinal pigment epithelium RPE1 cells (22.4).
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页数：10
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