CD16+ Macrophages: An Emerging Biomarker for Combined CTLA-4 and PD-1 Blockade

被引：0

作者：

Smithy, James W. ^{[1
]}

Luke, Jason J. ^{[2
,3
,4
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY USA

[2] UPMC Hillman Canc Ctr, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA

[4] UPMC Hillman Canc Ctr, Immunotherapy & Drug Dev Ctr, Pittsburgh, PA 15232 USA

来源：

CLINICAL CANCER RESEARCH | 2023年 / 29卷 / 13期

关键词：

IPILIMUMAB; THERAPY; NIVOLUMAB; MELANOMA;

D O I：

10.1158/1078-0432.CCR-23-0490

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a retrospective analysis of patients with unresectable melanoma, higher pretreatment tissue densities of CD16(+) macrophages were associated with clinical benefit from combined CTLA-4 and PD-1 blockade. With further validation, this biomarker could serve as a tool in selecting between immune checkpoint inhibitor regimens.

引用

页码：2345 / 2347

页数：3

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