Novavax NVX-COV2373 triggers neutralization of Omicron sub-lineages

被引：30

作者：

Bhiman, Jinal E. ^{[1
,2
]}

Richardson, Simone ^{[1
,2
]}

Lambson, Bronwen ^{[1
,2
]}

Kgagudi, Prudence ^{[1
,2
]}

Mzindle, Nonkululeko ^{[1
,2
]}

Kaldine, Haajira ^{[1
,2
]}

Crowther, Carol ^{[1
,2
]}

Gray, Glenda ^{[3
]}

Bekker, Linda-Gail ^{[4
,5
]}

Koen, Anthonet ^{[8
]}

Fairlie, Lee

Fouche, Leon

Bhorat, Qasim

Dheda, Keertan

Tameris, Michele

Masilela, Mduduzi

Hoosain, Zaheer

Singh, Nishanta

Hanley, Sherika ^{[8
]}

Archary, Moherndran

Louw, Cheryl

Grobbelaar, Coert

Lalloo, Umesh

Joseph, Natasha

Kruger, Gertruida

Shinde, Vivek ^{[6
]}

Bennett, Chijioke M. ^{[6
]}

Glenn, Gregory A. ^{[6
]}

Madhi, Shabir L. ^{[7
]}

Moore, Penny ^{[1
,2
,4
,8
]}

机构：

[1] Natl Inst Communicable Dis Natl Hlth Lab Serv, Johannesburg, South Africa

[2] Univ Witwatersrand, Sch Pathol, MRC Antibody Immun Res Unit, Johannesburg, South Africa

[3] South African Med Res Council, Tygerberg, South Africa

[4] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa

[5] Univ Cape Town, Desmond Tutu HIV Ctr, Cape Town, South Africa

[6] Novavax Inc, Gaithersburg, MD USA

[7] Univ Witwatersrand, Fac Hlth Sci, South Afr Med Res Council Vaccines, Infect Dis Analyt Res Unit, Johannesburg, South Africa

[8] Univ Kwazulu Natal, Ctr AIDS Programme Res South Africa, Durban, South Africa

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

D O I：

10.1038/s41598-023-27698-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The SARS-CoV-2 Omicron (B.1.1.529) Variant of Concern (VOC) and its sub-lineages (including BA.2, BA.4, BA.5, BA.2.12.1) contain spike mutations that confer high level resistance to neutralizing antibodies induced by vaccination with ancestral spike or infection with previously circulating variants. The NVX-CoV2373 vaccine, a protein nanoparticle vaccine containing the ancestral spike sequence, has value in countries with constrained cold-chain requirements. Here we report neutralizing titers following two or three doses of NVX-CoV2373. We show that after two doses, Omicron sub-lineages BA.1 and BA.4/BA.5 were resistant to neutralization by 72% (21/29) and 59% (17/29) of samples respectively. However, after a third dose of NVX-CoV2373, we observed high titers against Omicron BA.1 (GMT: 1,197) and BA.4/BA.5 (GMT: 582), with responses similar in magnitude to those triggered by three doses of an mRNA vaccine. These data are of particular relevance as BA.4/BA.5 is dominating in multiple locations, and highlight the potential utility of the NVX-CoV2373 vaccine as a booster in resource-limited environments.

引用

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