Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics

被引：128

作者：

Kar, Rishav ^{[1
]}

Dhar, Rajib ^{[2
]}

Mukherjee, Sayantanee ^{[3
]}

Nag, Sagnik ^{[4
]}

Gorai, Sukhamoy ^{[5
]}

Mukerjee, Nobendu ^{[6
,7
]}

Mukherjee, Dattatreya ^{[8
]}

Vatsa, Rishabh ^{[9
]}

Jadhav, Mamtha Chandrakanth ^{[10
]}

Ghosh, Arabinda ^{[11
]}

Devi, Arikketh ^{[2
,12
]}

Krishnan, Anand ^{[13
]}

Thorat, Nanasaheb D. ^{[10
,14
]}

机构：

[1] Ramakrishna Mission Vivekananda Educ & Res Inst, Dept Med Biotechnol, Howrah 711202, W Bengal, India

[2] SRM Inst Sci & Technol, Dept Genet Engn, Canc & Stem Cell Biol Lab, Kattankulathur 603203, Tamil Nadu, India

[3] Amrita Vishwa Vidyapeetham, Ctr Nanosci & Mol Med, Kochi 682041, Kerala, India

[4] Vellore Inst Technol VIT, Sch Biosci & Technol, Dept Biotechnol, Vellore 632014, Tamil Nadu, India

[5] Rush Univ, Med Ctr, Chicago, IL 60612 USA

[6] West Bengal State Univ, Dept Microbiol, Kolkata 700126, W Bengal, India

[7] Novel Global Community Educ Fdn, Dept Hlth Sci, Hebersham, Australia

[8] Raiganj Govt Med Coll & Hosp, Raiganj 733134, W Bengal, India

[9] Vels Inst Sci Technol & Adv Studies, Dept Microbiol, Chennai 600117, Tamilnadu, India

[10] Jawaharlal Nehru Med Coll, Bernal Inst, Dept Phys, Wardha 442001, Maharashtra, India

[11] Gauhati Univ, Dept Bot, Microbiol Div, Gauhati 781014, Assam, India

[12] SRM Inst Sci & Technol, Dept Genet Engn, Canc & Stem Cell Biol Lab, Kattankulathur 603203, Tamil Nadu, India

[13] Univ Free State, Fac Hlth Sci, Sch Pathol, Dept Chem Pathol, ZA-9300 Bloemfontein, Free State, South Africa

[14] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Womens & Reprod Hlth, Div Med Sci, Oxford OX1 2JD, England

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2023年 / 9卷 / 02期

基金：

爱尔兰科学基金会;

关键词：

Eexosomes; cancer; drug loading methods; drug delivery; cancer biomarker; MACROPHAGE-DERIVED EXOSOMES; EXTRACELLULAR VESICLES; IN-VITRO; COLORECTAL-CANCER; MICROVESICLES; VEHICLES; THERAPY; IMMUNOGENICITY; GLIOBLASTOMA; NANOVESICLES;

D O I：

10.1021/acsbiomaterials.2c01329

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from the plasma membrane. The main activity of exosomes is cellular communica-tion. In cancer, exosomes play an important rolefrom two distinct perspectives, one related to carcinogenesis and the other as theragnostic and drug delivery tools. The outer phospholipid membrane of Exosome improves drug targeting efficiency. . Some of the vital features of exosomes such as biocompatibility, low toxicity, and low immunogenicity make it a more exciting drug delivery system. Exosome-based drug delivery is a new innovative approach to cancer treatment. Exosome-associated biomarker analysis heralded a new era of cancer diagnostics in a more specific way. This Review focuses on exosome biogenesis, sources, isolation, interrelationship with cancer and exosome-related cancer biomarkers, drug loading methods, exosome-based biomolecule delivery, advances and limitations of exosome-based drug delivery, and exosome-based drug delivery in clinical settings studies. The exosome-based understanding of cancer will change the diagnostic and therapeutic approach in the future.

引用

页码：577 / 594

页数：18

共 158 条

[1] Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake [J].

Abels, Erik R. ;

Breakefield, Xandra O. .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2016, 36 (03) :301-312

[2] Milk exosomes: Nature's abundant nanoplatform for theranostic applications [J].

Adriano, Benilde ;

Cotto, Nycol M. ;

Chauhan, Neeraj ;

Jaggi, Meena ;

Chauhan, Subhash C. ;

Yallapu, Murali M. .

BIOACTIVE MATERIALS, 2021, 6 (08) :2479-2490

[3]

Airola Michael V, 2013, Handb Exp Pharmacol, P57, DOI 10.1007/978-3-7091-1368-4_3

[4] Naturally Occurring Exosome Vesicles as Potential Delivery Vehicle for Bioactive Compounds [J].

Akuma, Precious ;

Okagu, Ogadimma D. ;

Udenigwe, Chibuike C. .

FRONTIERS IN SUSTAINABLE FOOD SYSTEMS, 2019, 3

[5] Milk exosomes - Natural nanoparticles for siRNA delivery [J].

Aqil, Farrukh ;

Munagala, Radha ;

Jeyabalan, Jeyaprakash ;

Agrawal, Ashish K. ;

Kyakulaga, Al-Hassan ;

Wilcher, Sarah A. ;

Gupta, Ramesh C. .

CANCER LETTERS, 2019, 449 :186-195

[6] Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics [J].

Armstrong, James P. K. ;

Holme, Margaret N. ;

Stevens, Molly M. .

ACS NANO, 2017, 11 (01) :69-83

[7] Engineered targeting tLyp-1 exosomes as gene therapy vectors for efficient delivery of siRNA into lung cancer cells [J].

Bai, Jing ;

Duan, Jialun ;

Liu, Rui ;

Du, Yafei ;

Luo, Qian ;

Cui, Yinuo ;

Su, Zhanbo ;

Xu, Jiarui ;

Xie, Ying ;

Lu, Wanliang .

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 15 (04) :461-471

[8] Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences [J].

Balaj, Leonora ;

Lessard, Ryan ;

Dai, Lixin ;

Cho, Yoon-Jae ;

Pomeroy, Scott L. ;

Breakefield, Xandra O. ;

Skog, Johan .

NATURE COMMUNICATIONS, 2011, 2

[9] Transport of Extracellular Vesicles across the Blood-Brain Barrier: Brain Pharmacokinetics and Effects of Inflammation [J].

Banks, William A. ;

Sharma, Priyanka ;

Bullock, Kristin M. ;

Hansen, Kim M. ;

Ludwig, Nils ;

Whiteside, Theresa L. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (12) :1-21

[10] Using exosomes, naturally-equipped nanocarriers, for drug delivery [J].

Batrakova, Elena V. ;

Kim, Myung Soo .

JOURNAL OF CONTROLLED RELEASE, 2015, 219 :396-405

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