Electrochemical-Induced C-N Bond Formation: A New Method to Synthesis (Z)-Quinazolinone Oximes Using Primary Amines and Quinazolin-4(3H)-one

被引：2

作者：

Zong, Zhi-Min ^{[1
]}

Zhang, Lizhu ^{[1
]}

Li, Gan-Peng ^{[1
]}

Wang, Wei ^{[1
]}

Zhao, Xiao-Jing ^{[2
]}

He, Yonghui ^{[2
]}

机构：

[1] Yunnan Minzu Univ, Sch Ethn Med, Kunming 650500, Peoples R China

[2] Yunnan Minzu Univ, Sch Ethn Med, Key Lab Chem Ethn Med Resources, Kunming 650500, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 06期

关键词：

METAL-FREE; OXIDATION; FUNCTIONALIZATION; DERIVATIVES; INHIBITORS; CHEMISTRY; DESIGN;

D O I：

10.1021/acs.orglett.4c00107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and highly selective electrochemical method for the synthesis of diverse quinazolinone oximes via direct electrooxidation of primary amines/C-(sp(2))-H functionalization of oximes has been developed. The reaction is conducted in an undivided cell under constant current conditions and is oxidant-free, open-air, and eco-friendly. Notably, the protocol shows good functional group tolerance, providing versatile quinazolinone oximes in good yields. Moreover, the mechanism is investigated through control experiments and cyclic voltammogram (CV) experiments.

引用

页码：1271 / 1276

页数：6

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