Bone health in children with severe cerebral palsy

被引：0

作者：

Barbier, Vincent ^{[1
,2
,3
,4
,5
]}

Goeb, Vincent ^{[6
]}

Gouron, Richard ^{[5
,7
]}

Fritot, Severine ^{[4
]}

Mentaverri, Romuald ^{[5
,8
]}

Klein, Celine ^{[5
,7
]}

机构：

[1] Amiens Univ Hosp, Dept Paediat Phys Med & Rehabil, Amiens, France

[2] Jules Verne Univ Picardie, Amiens, France

[3] Three Valleys Rehabil Ctr, Victor Pauchet Grp, Corbie, France

[4] Corbie Hosp, Dept Paediat Phys Med & Rehabil, Corbie, France

[5] Jules Verne Univ Picardie, Amiens Univ Hosp, CURS, MP3CV UR UPJV 7517, Amiens, France

[6] Univ Picardie Jules Verne, Amiens Univ Hosp, Dept Rheumatol, Amiens, France

[7] Jules Verne Univ Picardie, Amiens Univ Hosp, Dept Paediat Orthopaed Surg, Amiens, France

[8] Jules Verne Univ Picardie, Amiens Univ Hosp, Dept Biochem & Endocrine Biol, Amiens, France

来源：

FRONTIERS IN PEDIATRICS | 2023年 / 11卷

关键词：

cerebral palsy; bone; low bone mineral density; osteoporosis; bone fragility; MINERAL DENSITY; CLASSIFICATION; GROWTH; EPIDEMIOLOGY; DEFINITION; RISK;

D O I：

10.3389/fped.2023.1264111

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

AimTo describe bone health and associated factors in children with severe cerebral palsy.MethodIn a retrospective, single-centre study, we performed a comprehensive bone evaluation (including clinical, densitometric and bone biomarker assessments) of children with severe cerebral palsy.ResultsNone of the 19 included children had a normal BMCTBLH Z score, and only one had a BMDTBLH Z score greater than -2. Six children had a BMDLS Z score greater than -2. The bone biomarker data were suggestive of excessive bone remodelling. Levels of bone remodelling markers factors and densitometric variables were not significantly related. Age, weight and pubertal stage were significantly related to bone mass.DiscussionOur results highlights the insufficient increase in bone mass with age (probably due to excessive bone remodelling) and confirms the high prevalence of low bone mineral density in children with severe cerebral palsy. Possible preventive measures might include calcium + vitamin D supplementation and the systematic management of underweight and delayed puberty. Bone remodelling markers might be of value for follow-up.

引用

页数：6

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