RISING STARS: Approaches to modeling placental function in preeclampsia in vitro and in vivo

被引:4
作者
Milano-Foster, Jessica [1 ]
Schulz, Laura C. [2 ]
机构
[1] Div Anim Sci, 245 Bond Life Sci Ctr,1201 Rollins Dr Univ Missou, Columbia, MO USA
[2] Dept Obstet Gynecol & Womens Hlth, N610 Med Sci Bldg, Columbia, MO 65211 USA
关键词
pregnancy; preeclampsia; placenta; modelling; trophoblast; UTERINE PERFUSION-PRESSURE; NITRIC-OXIDE SYNTHESIS; MOUSE MODEL; CHORIONIC-GONADOTROPIN; NONHUMAN-PRIMATES; ANIMAL-MODELS; EARLY-ONSET; RAT MODEL; HYPERTENSION; PREGNANCY;
D O I
10.1530/JOE-23-0008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Modeling preeclampsia remains difficult due to the nature of the disease and the unique characteristics of the human placenta. Members of the Hominidae superfamily have a villous hemochorial placenta that is different in structure from those of other therian mammals, including the mouse hemochorial placenta, making this common animal model less ideal for studying this disease. Human placental tissues delivered from pregnancies complicated by preeclampsia are excellent for assessing the damage the disease causes but cannot answer how or when the disease begins. Symptoms of preeclampsia manifest halfway through pregnancy or later, making it currently impossible to identify preeclampsia in human tissues obtained from an early stage of pregnancy. Many animal and cell culture models recapitulate various aspects of preeclampsia, though none can on its own completely capture the complexity of human preeclampsia. It is particularly difficult to uncover the cause of the disease using models in which the disease is induced in the lab. However, the many ways by which preeclampsia-like features can be induced in a variety of laboratory animals are consistent with the idea that preeclampsia is a two-stage disease, in which a variety of initial insults may lead to placental ischemia, and ultimately systemic symptoms. The recent development of stem cell-based models, organoids, and various coculture systems have brought in vitro systems with human cells ever closer to recapitulating in vivo events that lead to placental ischemia.
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页数:15
相关论文
共 121 条
[1]   SIMPLIFIED TECHNIQUE TO PRODUCE TOXEMIA IN THE RAT - CONSIDERATIONS ON CAUSE OF TOXEMIA [J].
ABITBOL, MM .
CLINICAL AND EXPERIMENTAL HYPERTENSION PART B-HYPERTENSION IN PREGNANCY, 1982, 1 (01) :93-103
[2]   HTR-8/SVneo cell line contains a mixed population of cells [J].
Abou-Kheir, Wassim ;
Barrak, Joanna ;
Hadadeh, Ola ;
Daoud, Georges .
PLACENTA, 2017, 50 :1-7
[3]   A New Mouse Model to Explore Therapies for Preeclampsia [J].
Ahmed, Abdulwahab ;
Singh, Jameel ;
Khan, Ysodra ;
Seshan, Surya V. ;
Girardi, Guillermina .
PLOS ONE, 2010, 5 (10)
[4]   Tumor necrosis factor-α-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expression [J].
Alexander, BT ;
Cockrell, KL ;
Massey, MB ;
Bennett, WA ;
Granger, JP .
AMERICAN JOURNAL OF HYPERTENSION, 2002, 15 (02) :170-175
[5]   Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide [J].
Alexander, BT ;
Kassab, SE ;
Miller, MT ;
Abram, SR ;
Reckelhoff, JF ;
Bennett, WA ;
Granger, JP .
HYPERTENSION, 2001, 37 (04) :1191-1195
[6]   Gestational Hypertension and Preeclampsia [J].
Espinoza, Jimmy ;
Vidaeff, Alex ;
Pettker, Christian M. ;
Simhan, Hyagriv .
OBSTETRICS AND GYNECOLOGY, 2020, 135 (06) :E237-E260
[7]  
[Anonymous], 2011, WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia
[8]  
August P., 2023, Preeclampsia: Clinical features and diagnosis
[9]   Animal models of preeclampsia: investigating pathophysiology and therapeutic targets [J].
Bakrania, Bhavisha A. ;
George, Eric M. ;
Granger, Joey P. .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2022, 226 (02) :S973-S987
[10]   Endometrial responses to embryonic signals in the primate [J].
Banerjee, Prajna ;
Fazleabas, Asgerally T. .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2010, 54 (2-3) :295-302