Molecular Docking, Synthesis of Novel Schiff Base 1, 3-Thiazine Compounds from 3-Methoxy Chalcone and Evaluation of Their Anxiolytic Activity

被引：0
|
作者：
Sonu [1 ]
Gautam, Girendra Kumar [2 ]
Mishra, Arun Kumar [3 ]
Parveen, Baby Rabiya [3 ]
Saini, Rajat [2 ]
Singh, Harpreet [1 ]
机构：
[1] IFTM Univ, Fac Pharm, Sch Pharmaceut Sci, Moradabad 244102, India
[2] Shri Ram Coll Pharm, Dept Pharmaceut Chem, Muzaffarnagar 251001, India
[3] IFTM Univ, Pharm Acad, Fac Pharm, Moradabad 244102, India
来源：
ORIENTAL JOURNAL OF CHEMISTRY | 2023年 / 39卷 / 03期
关键词：
Chalcone; Schiff base 1; 3-thiazine derivative; Anxiolytic; Computational studies; ELEVATED PLUS-MAZE; ANXIETY;
D O I：
10.13005/ojc/390326
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As they represent a sizable class of naturally occurring and synthetic chemicals with potent biological activity in the pharmaceutical and biological fields, 1, 3 Thiazine heterocycles are of great interest. The goal of this project was to create the Schiff base. 3,-Methoxychalcone derivative of 1,3-thiazine. TLC, IR, 1HNMR, 13C NMR, each mass calculation were accustomed to identify the compositions of recently created targeted substances. Using an Elevated plus maze, the test compounds (B1-11) were examined for their ability to reduce anxiety. The most effective CNS medications were B1 and B8 compounds.
引用
收藏
页码：746 / 754
页数：9
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