Molecular Docking, Synthesis of Novel Schiff Base 1, 3-Thiazine Compounds from 3-Methoxy Chalcone and Evaluation of Their Anxiolytic Activity

被引：0

作者：

Sonu ^{[1
]}

Gautam, Girendra Kumar ^{[2
]}

Mishra, Arun Kumar ^{[3
]}

Parveen, Baby Rabiya ^{[3
]}

Saini, Rajat ^{[2
]}

Singh, Harpreet ^{[1
]}

机构：

[1] IFTM Univ, Fac Pharm, Sch Pharmaceut Sci, Moradabad 244102, India

[2] Shri Ram Coll Pharm, Dept Pharmaceut Chem, Muzaffarnagar 251001, India

[3] IFTM Univ, Pharm Acad, Fac Pharm, Moradabad 244102, India

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2023年 / 39卷 / 03期

关键词：

Chalcone; Schiff base 1; 3-thiazine derivative; Anxiolytic; Computational studies; ELEVATED PLUS-MAZE; ANXIETY;

D O I：

10.13005/ojc/390326

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As they represent a sizable class of naturally occurring and synthetic chemicals with potent biological activity in the pharmaceutical and biological fields, 1, 3 Thiazine heterocycles are of great interest. The goal of this project was to create the Schiff base. 3,-Methoxychalcone derivative of 1,3-thiazine. TLC, IR, 1HNMR, 13C NMR, each mass calculation were accustomed to identify the compositions of recently created targeted substances. Using an Elevated plus maze, the test compounds (B1-11) were examined for their ability to reduce anxiety. The most effective CNS medications were B1 and B8 compounds.

引用

页码：746 / 754

页数：9

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