More accurate prediction of treatment response than mean apparent diffusion coefficient value in multiple myeloma using whole body MRI histogram analysis

被引：0

作者：

Qi, Qingyan ^{[1
,9
]}

Dong, Huazheng ^{[2
]}

Ji, Xiaodong ^{[3
]}

Zhang, Kemin ^{[4
,5
]}

Zou, Dehui ^{[5
,6
]}

Hao, Mu ^{[5
,6
]}

Deng, Shuhui ^{[5
,6
]}

Sui, Weiwei ^{[5
,6
]}

Song, Zhiyi ^{[2
]}

Yu, Zhuo ^{[7
]}

Shen, Zhiwei ^{[8
]}

Huang, Wenyang ^{[5
,6
]}

Xia, Shuang ^{[3
]}

机构：

[1] Tianjin Med Univ, Cent Clin Sch 1, Tianjin, Peoples R China

[2] Tianjin Acad Tradit Chinese Med, Affiliated Hosp, Dept Radiol, Tianjin 300120, Peoples R China

[3] Nankai Univ, Tianjin Cent Hosp 1, Med Imaging Inst Tianjin, Sch Med,Dept Radiol, Tianjin 300192, Peoples R China

[4] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Haihe Lab Cell Ecosyst, Natl Clin Res Ctr Blood Dis,Dept Radiol,State Key, Tianjin 300020, Peoples R China

[5] Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin 300020, Peoples R China

[6] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, Haihe Lab Cell Ecosyst,State Key Lab Expt Hematol,, Tianjin 300020, Peoples R China

[7] Tianjin Ninghe Hosp, Dept Radiol, Tianjin, Peoples R China

[8] World Profit Ctr, Philips Healthcare Scientif Res Support, Beijing 100020, Peoples R China

[9] Shanxi Eye Hosp, Dept Radiol, 100 Fu Dong St, Taiyuan, Shanxi, Peoples R China

来源：

FUTURE ONCOLOGY | 2023年 / 19卷 / 17期

基金：

中国国家自然科学基金;

关键词：

ADC; histogram analysis; multiple myeloma; treatment response; whole body MRI; FAT FRACTION; DISEASE; CANCER; OUTCOMES; ADC;

D O I：

10.2217/fon-2023-0205

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To assess baseline histogram parameters from apparent diffusion coefficient (ADC) images in predicting early treatment response in newly diagnosed multiple myeloma (NDMM) patients. Methods: The histogram parameters of lesions in 68 NDMM patients were obtained with the Firevoxel software. The presence of deep response after two cycles of induction was recorded. Results: Some parameters were significantly different between the two groups, for example, ADC 75% in lumbar spine (p = 0.026). No significant difference in mean ADC for any anatomic site was found (all p > 0.05). The combination of ADC 75, ADC 90 and ADC 95% in lumbar spine; ADC skewness and ADC kurtosis in rib achieved a sensitivity of 100% in predicting deep response. Conclusion: Histogram analysis of ADC images can describe NDMM heterogeneity and accurately predict treatment response.

引用

页码：1175 / 1185

页数：11

共 43 条

[41] Prospective Comparison of 18-FDG PET/CT and Whole-Body MRI with Diffusion-Weighted Imaging in the Evaluation of Treatment Response of Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplant
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[42] Extended Texture Analysis of Non-Enhanced Whole-Body MRI Image Data for Response Assessment in Multiple Myeloma Patients Undergoing Systemic Therapy
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[43] Differentiation of Diffuse Infiltration Pattern in Multiple Myeloma From Hyperplastic Hematopoietic Bone Marrow: Qualitative and Quantitative Analysis Using Whole-Body MRI
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JOURNAL OF MAGNETIC RESONANCE IMAGING, 2022, 55 (04) : 1213 - 1225

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