More accurate prediction of treatment response than mean apparent diffusion coefficient value in multiple myeloma using whole body MRI histogram analysis

被引：0
|
作者：
Qi, Qingyan [1 ,9 ]
Dong, Huazheng [2 ]
Ji, Xiaodong [3 ]
Zhang, Kemin [4 ,5 ]
Zou, Dehui [5 ,6 ]
Hao, Mu [5 ,6 ]
Deng, Shuhui [5 ,6 ]
Sui, Weiwei [5 ,6 ]
Song, Zhiyi [2 ]
Yu, Zhuo [7 ]
Shen, Zhiwei [8 ]
Huang, Wenyang [5 ,6 ]
Xia, Shuang [3 ]
机构：
[1] Tianjin Med Univ, Cent Clin Sch 1, Tianjin, Peoples R China
[2] Tianjin Acad Tradit Chinese Med, Affiliated Hosp, Dept Radiol, Tianjin 300120, Peoples R China
[3] Nankai Univ, Tianjin Cent Hosp 1, Med Imaging Inst Tianjin, Sch Med,Dept Radiol, Tianjin 300192, Peoples R China
[4] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Haihe Lab Cell Ecosyst, Natl Clin Res Ctr Blood Dis,Dept Radiol,State Key, Tianjin 300020, Peoples R China
[5] Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin 300020, Peoples R China
[6] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, Haihe Lab Cell Ecosyst,State Key Lab Expt Hematol,, Tianjin 300020, Peoples R China
[7] Tianjin Ninghe Hosp, Dept Radiol, Tianjin, Peoples R China
[8] World Profit Ctr, Philips Healthcare Scientif Res Support, Beijing 100020, Peoples R China
[9] Shanxi Eye Hosp, Dept Radiol, 100 Fu Dong St, Taiyuan, Shanxi, Peoples R China
来源：
FUTURE ONCOLOGY | 2023年 / 19卷 / 17期
基金：
中国国家自然科学基金;
关键词：
ADC; histogram analysis; multiple myeloma; treatment response; whole body MRI; FAT FRACTION; DISEASE; CANCER; OUTCOMES; ADC;
D O I：
10.2217/fon-2023-0205
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To assess baseline histogram parameters from apparent diffusion coefficient (ADC) images in predicting early treatment response in newly diagnosed multiple myeloma (NDMM) patients. Methods: The histogram parameters of lesions in 68 NDMM patients were obtained with the Firevoxel software. The presence of deep response after two cycles of induction was recorded. Results: Some parameters were significantly different between the two groups, for example, ADC 75% in lumbar spine (p = 0.026). No significant difference in mean ADC for any anatomic site was found (all p > 0.05). The combination of ADC 75, ADC 90 and ADC 95% in lumbar spine; ADC skewness and ADC kurtosis in rib achieved a sensitivity of 100% in predicting deep response. Conclusion: Histogram analysis of ADC images can describe NDMM heterogeneity and accurately predict treatment response.
引用
收藏
页码：1175 / 1185
页数：11
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