We proposed the Hermitian manifold numerical method (HNMM) fitted for finite strain analysis of thin plates with irregular domains. The large deflection of elastic thin plates is generally characterized by Foppl-von Karman (FvK) equations, coupled with nonlinear fourth-order partial differential equations. The corresponding primal variational formulation requires the solution function to be globally C-1 continuous but piecewise C-2 continuous (namely H-2 regular). Hermitian numerical manifold method (HNMM) can easily construct an approximation to solutions that satisfy the H-2 regular requirements with structured meshes. Furthermore, those classical plate elements in finite element history can be embedded in the framework of HNMM and be more flexible and adaptable to solve plates with irregular domains. Thus, HNMM is formulated based on the Foppl-von Karman (FvK) model using the dual cover system and a triplet attributes group on the physical patches. The numerical results demonstrate the accuracy of HNMM in large deflection of Foppl-von Karman plate with complex domain shape.