Overview of growth differentiation factor 15 in metabolic syndrome

被引：36

作者：

Asrih, Mohamed ^{[1
,2
]}

Wei, Shibo ^{[3
]}

Nguyen, Thanh T. ^{[4
,5
]}

Yi, Hyon-Seung ^{[6
,7
]}

Ryu, Dongryeol ^{[3
,4
,5
]}

Gariani, Karim ^{[1
,2
,8
,9
]}

机构：

[1] Geneva Univ Hosp, Div Endocrinol Diabetol Nutr & Therapeut Patient E, Geneva, Switzerland

[2] Univ Geneva, Med Sch, Diabet Ctr Fac Med, Geneva, Switzerland

[3] Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon, South Korea

[4] Sungkyunkwan Univ SKKU, Inst Quantum Biophys, Dept Biophys, Suwon, South Korea

[5] Gwangju Inst Sci & Technol GIST, Dept Biomed Sci & Engn, Gwangju, South Korea

[6] Chungnam Natl Univ, Sch Med, Lab Endocrinol & Immune Syst, Daejeon, South Korea

[7] Chungnam Natl Univ, Sch Med, Dept Med Sci, Daejeon, South Korea

[8] Geneva Univ Hosp, Div Endocrinol Diabetol Nutr & Therapeut Patient E, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland

[9] Univ Geneva, Med Sch, Diabet Ctr Fac Med, CH-1211 Geneva, Switzerland

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2023年 / 27卷 / 09期

关键词：

growth differentiation factor 15; inflammatory state; metabolic syndrome; obesity; MACROPHAGE INHIBITORY CYTOKINE; BETA SUPERFAMILY MEMBER; DIABETES-MELLITUS; TRANSGENIC MICE; WEIGHT-LOSS; OBESITY; GDF15; RECEPTOR; EXPRESSION; PROTECTS;

D O I：

10.1111/jcmm.17725

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Growth and differentiation factor 15 (GDF15) is a member of the transforming growth factor-beta (TGF-beta) superfamily. GDF15 has been linked with several metabolic syndrome pathologies such as obesity and cardiovascular diseases. GDF15 is considered to be a metabolic regulator, although its precise mechanisms of action remain to be determined. Glial cell-derived neurotrophic factor family receptor alpha-like (GRAL), located in the hindbrain, has been identified as the receptor for GDF15 and signals through the coreceptor receptor tyrosine kinase (RET). Administration of GDF15 analogues in preclinical studies using various animal models has consistently been shown to induce weight loss through a reduction in food intake. GDF15, therefore, represents an attractive target to combat the current global obesity epidemic. In this article, we review current knowledge on GDF15 and its involvement in metabolic syndrome.

引用

页码：1157 / 1167

页数：11

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