Overview of growth differentiation factor 15 in metabolic syndrome

被引：32

作者：

Asrih, Mohamed ^{[1
,2
]}

Wei, Shibo ^{[3
]}

Nguyen, Thanh T. ^{[4
,5
]}

Yi, Hyon-Seung ^{[6
,7
]}

Ryu, Dongryeol ^{[3
,4
,5
]}

Gariani, Karim ^{[1
,2
,8
,9
]}

机构：

[1] Geneva Univ Hosp, Div Endocrinol Diabetol Nutr & Therapeut Patient E, Geneva, Switzerland

[2] Univ Geneva, Med Sch, Diabet Ctr Fac Med, Geneva, Switzerland

[3] Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon, South Korea

[4] Sungkyunkwan Univ SKKU, Inst Quantum Biophys, Dept Biophys, Suwon, South Korea

[5] Gwangju Inst Sci & Technol GIST, Dept Biomed Sci & Engn, Gwangju, South Korea

[6] Chungnam Natl Univ, Sch Med, Lab Endocrinol & Immune Syst, Daejeon, South Korea

[7] Chungnam Natl Univ, Sch Med, Dept Med Sci, Daejeon, South Korea

[8] Geneva Univ Hosp, Div Endocrinol Diabetol Nutr & Therapeut Patient E, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland

[9] Univ Geneva, Med Sch, Diabet Ctr Fac Med, CH-1211 Geneva, Switzerland

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2023年 / 27卷 / 09期

关键词：

growth differentiation factor 15; inflammatory state; metabolic syndrome; obesity; MACROPHAGE INHIBITORY CYTOKINE; BETA SUPERFAMILY MEMBER; DIABETES-MELLITUS; TRANSGENIC MICE; WEIGHT-LOSS; OBESITY; GDF15; RECEPTOR; EXPRESSION; PROTECTS;

D O I：

10.1111/jcmm.17725

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Growth and differentiation factor 15 (GDF15) is a member of the transforming growth factor-beta (TGF-beta) superfamily. GDF15 has been linked with several metabolic syndrome pathologies such as obesity and cardiovascular diseases. GDF15 is considered to be a metabolic regulator, although its precise mechanisms of action remain to be determined. Glial cell-derived neurotrophic factor family receptor alpha-like (GRAL), located in the hindbrain, has been identified as the receptor for GDF15 and signals through the coreceptor receptor tyrosine kinase (RET). Administration of GDF15 analogues in preclinical studies using various animal models has consistently been shown to induce weight loss through a reduction in food intake. GDF15, therefore, represents an attractive target to combat the current global obesity epidemic. In this article, we review current knowledge on GDF15 and its involvement in metabolic syndrome.

引用

页码：1157 / 1167

页数：11

共 94 条

[11] Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia [J].

Baek, Seung Joon ;

Okazaki, Ryuji ;

Lee, Seong-Ho ;

Martinez, Jeanelle ;

Kim, Jong-Sik ;

Yamaguchi, Kiyoshi ;

Mishina, Yuji ;

Martin, David W. ;

Shoieb, Ahmed ;

Mcentee, Michael F. ;

Eling, Thomas E. .

GASTROENTEROLOGY, 2006, 131 (05) :1553-1560

[12] The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-β superfamily member, acts as a quality control determinant for correctly folded MIC-1 [J].

Bauskin, AR ;

Zhang, HP ;

Fairlie, WD ;

He, XY ;

Russell, PK ;

Moore, AG ;

Brown, DA ;

Stanley, KK ;

Breit, SN .

EMBO JOURNAL, 2000, 19 (10) :2212-2220

[13] The TGF-β Superfamily Cytokine MIC-1/GDF15: Secretory Mechanisms Facilitate Creation of Latent Stromal Stores [J].

Bauskin, Asne R. ;

Jiang, Lele ;

Luo, X. Wei ;

Wu, Liyun ;

Brown, David A. ;

Breit, Samuel N. .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2010, 30 (06) :389-397

[14] Characterization of atherosclerotic plaques in blood vessels with low oxygenated blood and blood pressure (Pulmonary trunk): role of growth differentiation factor-15 (GDF-15) [J].

Bonaterra, G. A. ;

Struck, N. ;

Zuegel, S. ;

Schwarz, A. ;

Mey, L. ;

Schwarzbach, H. ;

Strelau, J. ;

Kinscherf, R. .

BMC CARDIOVASCULAR DISORDERS, 2021, 21 (01)

[15] Growth Differentiation Factor-15 Deficiency Inhibits Atherosclerosis Progression by Regulating Interleukin-6-Dependent Inflammatory Response to Vascular Injury [J].

Bonaterra, Gabriel A. ;

Zuegel, Stefanie ;

Thogersen, Joel ;

Walter, Sabrina A. ;

Haberkorn, Uwe ;

Strelau, Jens ;

Kinscherf, Ralf .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2012, 1 (06) :e002550

[16] MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily [J].

Bootcov, MR ;

Bauskin, AR ;

Valenzuela, SM ;

Moore, AG ;

Bansal, M ;

He, XY ;

Zhang, HP ;

Donnellan, M ;

Mahler, S ;

Pryor, K ;

Walsh, BJ ;

Nicholson, RC ;

Fairlie, WD ;

Por, SB ;

Robbins, JM ;

Breit, SN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (21) :11514-11519

[17] The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe? [J].

Breit, Samuel N. ;

Brown, David A. ;

Tsai, Vicky Wang-Wei .

ANNUAL REVIEW OF PHYSIOLOGY, VOL 83, 2021, 83 :127-151

[18] Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study [J].

Cheung, Ching-Lung ;

Tan, Kathryn C. B. ;

Au, Philip C. M. ;

Li, Gloria H. Y. ;

Cheung, Bernard M. Y. .

EBIOMEDICINE, 2019, 41 :85-90

[19] Body weight regulation via MT1-MMP-mediated cleavage of GFRAL [J].

Chow, Chi Fung Willis ;

Guo, Xuanming ;

Asthana, Pallavi ;

Zhang, Shuo ;

Wong, Sheung Kin Ken ;

Fallah, Samane ;

Che, Sijia ;

Gurung, Susma ;

Wang, Zening ;

Lee, Ki Baek ;

Ge, Xin ;

Yuan, Shiyang ;

Xu, Haoyu ;

Ip, Jacque Pak Kan ;

Jiang, Zhixin ;

Zhai, Lixiang ;

Wu, Jiayan ;

Zhang, Yijing ;

Mahato, Arun Kumar ;

Saarma, Mart ;

Lin, Cheng Yuan ;

Kwan, Hiu Yee ;

Huang, Tao ;

Lyu, Aiping ;

Zhou, Zhongjun ;

Bian, Zhao-Xiang ;

Wong, Hoi Leong Xavier .

NATURE METABOLISM, 2022, 4 (02) :203-+

[20] NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism [J].

Chrysovergis, K. ;

Wang, X. ;

Kosak, J. ;

Lee, S-H ;

Kim, J. S. ;

Foley, J. F. ;

Travlos, G. ;

Singh, S. ;

Baek, S. J. ;

Eling, T. E. .

INTERNATIONAL JOURNAL OF OBESITY, 2014, 38 (12) :1555-1564

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