Multicomponent mathematical model for tumor volume calculation with setup error using single-isocenter stereotactic radiotherapy for multiple brain metastases

被引：2

作者：

Nakano, Hisashi ^{[1
,2
]}

Shiinoki, Takehiro ^{[3
]}

Tanabe, Satoshi ^{[1
]}

Nakano, Toshimichi ^{[4
]}

Takizawa, Takeshi ^{[4
,5
]}

Utsunomiya, Satoru ^{[6
]}

Sakai, Madoka ^{[1
]}

Tanabe, Shunpei ^{[1
]}

Ohta, Atsushi ^{[1
]}

Kaidu, Motoki ^{[4
]}

Nishio, Teiji ^{[2
]}

Ishikawa, Hiroyuki ^{[4
]}

机构：

[1] Niigata Univ Med & Dent Hosp, Dept Radiat Oncol, 1-757 Asahimachi Dori,Chuo Ku, Niigata, Niigata, Japan

[2] Osaka Univ, Dept Med Phys & Engn, Grad Sch Med, 1-7 Yamadaoka, Suita, Osaka, Japan

[3] Yamaguchi Univ, Dept Radiat Oncol, Minamikogushi 1-1-1, Ube, Yamaguchi, Japan

[4] Niigata Univ, Dept Radiol & Radiat Oncol, Grad Sch Med & Dent Sci, 1-757 Asahimachi Dori,Chuo Ku, Niigata, Niigata, Japan

[5] Niigata Neurosurg Hosp, Dept Radiat Oncol, 3057 Yamada,Nishi Ku, Niigata, Niigata, Japan

[6] Niigata Univ, Dept Radiol Technol, Grad Sch Hlth Sci, 2-746 Asahimachi Dori,Chuo Ku, Niigata, Niigata, Japan

来源：

PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE | 2023年 / 46卷 / 02期

基金：

日本学术振兴会;

关键词：

Single-isocenter technique; Stereotactic radiotherapy; Brain metastasis; Setup error; Multicomponent model; Ordinary differential equation; RADIOSURGERY; CANCER; RESECTION; SURVIVAL; CELLS; VMAT; TIME;

D O I：

10.1007/s13246-023-01241-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We evaluated the tumor residual volumes considering six degrees-of-freedom (6DoF) patient setup errors in stereotactic radiotherapy (SRT) with multicomponent mathematical model using single-isocenter irradiation for brain metastases. Simulated spherical gross tumor volumes (GTVs) with 1.0 (GTV 1), 2.0 (GTV 2), and 3.0 (GTV 3)-cm diameters were used. The distance between the GTV center and isocenter (d) was set at 0-10 cm. The GTV was simultaneously translated within 0-1.0 mm (T) and rotated within 0 degrees-1.0 degrees (R) in the three axis directions using affine transformation. We optimized the tumor growth model parameters using measurements of non-small cell lung cancer cell lines' (A549 and NCI-H460) growth. We calculated the GTV residual volume at the irradiation's end using the physical dose to the GTV when the GTV size, d, and 6DoF setup error varied. The d-values that satisfy tolerance values (10%, 35%, and 50%) of the GTV residual volume rate based on the pre-irradiation GTV volume were determined. The larger the tolerance value set for both cell lines, the longer the distance to satisfy the tolerance value. In GTV residual volume evaluations based on the multicomponent mathematical model on SRT with single-isocenter irradiation, the smaller the GTV size and the larger the distance and 6DoF setup error, the shorter the distance that satisfies the tolerance value might need to be.

引用

页码：945 / 953

页数：9

共 52 条

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