Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?

被引：4
作者：
Di Somma, Carolina [1 ,2 ]
Scarano, Elisabetta [1 ]
Arianna, Rossana [1 ]
Romano, Fiammetta [1 ]
Lavorgna, Mariarosaria [1 ]
Serpico, Domenico [1 ]
Colao, Annamaria [1 ,2 ]
机构：
[1] Univ Naples Federico II, Dept Clin Med & Surg, Endocrinol Diabet & Androl Unit, I-80131 Naples, Italy
[2] Univ Naples Federico II, UNESCO Chair Educ Hlth & Sustainable Dev, I-80131 Naples, Italy
来源：
JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 02期
关键词：
GH treatment; cancer risk; GHD; NONFUNCTIONING PITUITARY-ADENOMA; CHILDHOOD-CANCER; REPLACEMENT THERAPY; FACTOR-I; HYPOPITUITARY PATIENTS; SUBSEQUENT NEOPLASMS; 2ND NEOPLASMS; BRAIN-TUMORS; RADIATION-THERAPY; ENDOCRINE-SOCIETY;
D O I：
10.3390/jcm12020662
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth. Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence excess of de novo cancers, and several reports on children and adults treated with GH have not shown an increase in observed cancer risk in these patients. The aim of this review is to provide an at-a-glance overview and the state of the art of long-term effects of GH replacement on neoplastic risk in adults with growth hormone deficiency who have survived cancer and sellar tumors.
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页数：15
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